SRP3327
IL-1 RECEPTOR ANTAGONIST human
Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
ICIL-1RA, IL-1RN, IL-1Ra, IRAP
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (HPLC), ≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
17.2 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC), ≥98% (SDS-PAGE)
form
lyophilized
potency
20-40 ng/mL
mol wt
17.2 kDa
packaging
pkg of 100 μg
storage condition
(Keep container tightly closed in a dry and well-ventilated place)
technique(s)
activity assay: suitable
impurities
endotoxin, tested
color
white to off-white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1R1(3554)
General description
Research area: Immunology & cytokines
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.
Application
Interleukin-1 receptor antagonist (IL-1RA) human has been used:
- to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin
- to block the IL-1β binding to its receptor
- to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.
Physical form
Lyophilized from 20 mM Tris, pH 8.0.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Association of IL-1a rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study.
He F
International Journal of Clinical and Experimental Pathology, 8, 4182-4185 (2015)
The role of cytokines in cancer-related fatigue.
Kurzrock R
Cancer, 92, 1684-1688 (2001)
Exposure of T lymphocytes to leflunomide but not to dexamethasone favors the production by monocytic cells of interleukin-1 receptor antagonist and the tissue-inhibitor of metalloproteinases-1 over that of interleukin-1beta and metalloproteinases.
Deage V
European Cytokine Network, 9, 663-668 (1998)
Expression of interleukin-1 beta (IL-1beta) and interleukin-1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium.
Sousa AR
American Journal of Respiratory and Critical Care Medicine, 154, 1061-1066 (1996)
Hyperresponsive febrile reactions to interleukin (IL) 1alpha and IL-1beta, and altered brain cytokine mRNA and serum cytokine levels, in IL-1beta-deficient mice.
Alheim K
Proceedings of the National Academy of Sciences of the USA, 94, 2681-2686 (1997)
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