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SRP3327

IL-1 RECEPTOR ANTAGONIST human

Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

ICIL-1RA, IL-1RN, IL-1Ra, IRAP

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (HPLC)
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
17.2 kDa

Key Documents

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Product Name

IL-1 RECEPTOR ANTAGONIST human, Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

potency

20-40 ng/mL

mol wt

17.2 kDa

packaging

pkg of 100 μg

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

impurities

endotoxin, tested

color

white to off-white

UniProt accession no.

P14778

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL1R1(3554)

Application

Interleukin-1 receptor antagonist (IL-1RA) human has been used:
  • to study the role of interleukin (IL)-1β receptor in cell senescence induced by doxorubicin
  • to block the IL-1β binding to its receptor
  • to understand the role of autocrine interleukin-1β (IL-1β) signaling downstream of cl- in RPS27 modulation

Biochem/physiol Actions

Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.

General description

Research area: Immunology & cytokines

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein. IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Recombinant human IL-1Ra is a 17.2kDa protein consisting of 153 amino acid residues.

Physical form

Lyophilized from 20 mM Tris, pH 8.0.

Preparation Note

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0213AFC474
0107S243

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Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock.
Arnalich F
The Journal of Infectious Diseases, 180, 908-911 (1999)
Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
Bioque G
Clinical and Experimental Immunology, 102, 379-383 (1995)
Disruption of interleukin-1? autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.
Clauzure M
PLoS ONE, 9, e99257-e99257 (2014)
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
Bresnihan B
Arthritis and Rheumatism, 41, 2196-2204 (1998)
Association of IL-1a rs17561 and IL-1 RN rs315952 polymorphisms with Tourette syndrome: a family-based study.
He F
International Journal of Clinical and Experimental Pathology, 8, 4182-4185 (2015)
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