SRP4038
Fgf-2 from mouse
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Synonym(s):
FGF-b, Fibroblast Growth Factor-basic, HBGF-2 Prostatropin
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About This Item
biological source
mouse
recombinant
expressed in E. coli
assay
≥95% (HPLC), ≥95% (SDS-PAGE)
form
lyophilized
mol wt
~16.3 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Fgf2(14173)
General description
FGF-2 (fibroblast growth factor 2) is a basic heparin binding growth factor. It is ubiquitously expressed and belongs to the FGF family. It is also referred to as BFGF (basic fibroblast growth factor). The recombinant mouse FGF-2 is a single, non-glycosylated chain containing 145 amino acids and having a molecular weight of 16.3kDa.
Biochem/physiol Actions
FGF-2 (fibroblast growth factor 2, also referred to as BFGF (basic fibroblast growth factor)) stimulates the proliferation of a wide variety of cells including mesenchymal, neuroectodermal and endothelial cells. It is present in the preimplantation embryos and is important for proper development. It is also responsible for angiogenesis. FGF-2 plays a crucial role in adipogenesis and development of adipose tissues. It is associated with tumor growth and metastasis.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile water to 100 μg/mL.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Biphasic effects of FGF2 on adipogenesis.
Kim S
PLoS ONE, 10, e0120073-e0120073 (2015)
Blocking FGF2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings.
de Aguiar RB
Cancer Letters, 371, 151-160 (2016)
Binding of FGF2 to FGFR2 in an autocrine mode in trophectoderm cells is indispensable for mouse blastocyst formation through PKC-p38 pathway.
Yang J
Cell Cycle, 14, 3318-3330 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP4038-50UG | 04061837226083 |