SRP4134
IL-3 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonym(s):
HCGF, IL-3, Interleukin-3, MCGF (Mast cell growth factor), MGC79398, Multi-CSF, P-cell stimulation factor
Product Name
IL-3 human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
biological source
human
recombinant
expressed in E. coli
assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~15.0 kDa
packaging
pkg of 10 μg
impurities
endotoxin, tested
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL3(3562)
Biochem/physiol Actions
Interleukin-3 (IL-3) is a hematopoietic growth factor. The gene encoding it is localized on human chromosome 5. It has a role in cell proliferation and activates different signaling cascades. It is crucial for the differentiation of hematopoietic-derived endothelial progenitor cells (EPCs). The differentiation of erythroid cells, mast cells and granulocytes is stimulated by IL-3. The protein has been linked to schizophrenia.
General description
IL-3 is a species-specific colony-stimulating factor that stimulates colony formation of megakaryocytes, neutrophils, and macrophages from bone marrow cultures. Recombinant human IL-3 is a 15.0 kDa protein containing 133 amino acid residues.
Physical form
Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
The inducible tissue-specific expression of the human IL-3/GM-CSF locus is controlled by a complex array of developmentally regulated enhancers.
Baxter EW
Journal of Immunology (2012)
Association of interleukin 3 (IL-3) polymorphisms with schizophrenia in Han Chinese population.
Liu Z
Neuroscience Letters (2015)
The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors.
Luo XJ
PLoS ONE (2012)
IL-3 is a novel target to interfere with tumor vasculature.
Dentelli P
Oncogene (2011)
IL3 variant on chromosomal region 5q31-33 and protection from recurrent malaria attacks.
Meyer CG
Human Molecular Genetics (2011)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service