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SRP4137

IL-4 human

Name: IL-4 human
Brand: SIGMA

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)

Synonym(s):

B cell stimulating factor, BCDF, BCGF, BSF-1, IL-4, Lymphocyte stimulatory factor 1

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About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD00151705

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Properties

biological source

human

recombinant

expressed in E. coli

assay

≥98% (HPLC), ≥98% (SDS-PAGE)

form

lyophilized

mol wt

~15.0 kDa

packaging

pkg of 10 μg

impurities

endotoxin, tested

NCBI accession no.

P05112

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... IL4(3565)

Description

General description

The gene IL-4 (interleukin 4) is mapped to human chromosome 5q31.1. Human IL-4 is a 15kDa globular protein containing 130 amino acid residues. It is a cytokine which is mainly secreted by activated Th2 (T helper) cells.

Application

In inflamed porcine endometrium, IL-4 (interleukin 4)-human has been used to study effects of IL-4 on the leukotriene B4 and leukotriene C4 synthesis as well as secretion. It has been used to study the effect of IL-4 on synthesis and secretion of leukotrienes from endometrial epithelial cells of pigs.

IL-4 (interleukin 4) has been used to polarize the human monocytic leukemia (THP-1) cells to M2-like phenotype.

Biochem/physiol Actions

IL-4 (Interleukin 4) is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It exhibits anti-inflammatory responses and participates in immune processes by providing protection from intracellular pathogens. IL-4 also plays an important role in Th2 (T helper cells) differentiation. Additionally, it can suppress pro-inflammatory cytokines. IL-4 is associated with pemphigus. Also, mutation in the gene is linked with risk of dental implant loss. In children, IL-4 might be involved with risk of asthma and Mycoplasma pneumoniae infection.

Physical form

Sterile filtered and lyophilized with no additives.

Preparation Note

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. The solution can then be diluted into other aqueous buffers.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c