biological source
human
recombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~15.4 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LGALS7(3963)
General description
LGALS7 (galectin-7) is from the galectin family of β-galactoside-binding proteins. It is mainly present in the stratified epithelia, hair follicles and thymic Hassall′s corpuscles. The protein localizes in the nucleus and cytoplasm, and exists as a homodimer. Recombinant Human Galectin-7 is a 15.4kDa protein consisting of 136 amino acid residues
Biochem/physiol Actions
LGALS7 (galectin-7) helps in maintaining skin homeostasis, particularly after skin injury. It is also involved in keratinocyte proliferation and differentiation via JNK1 (c-Jun N-terminal kinase)-miR-203-p63 pathway. LGALS7 is a biomarker for skin condition and skin barrier disruption. In HeLa cells, it induces apoptosis most likely via JNK signaling. LGALS7 is downregulated in SV40-transformed cells and squamous cell carcinoma cells. Change in its activity/expression is associated with the progression of various epithelia-associated cancers. LGALS7 also helps in postmenstrual endometrial re-epithelialization.
Physical form
Sterile filtered and Lyophilized without additives.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
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