SRP4972
GHBP human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
Synonym(s):
GH receptor, GHBP, GHR, Somatotropin receptor
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥98% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~28.1 kDa
biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
mol wt
~28.1 kDa
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... GHR(2690)
General description
GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.
The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding.
The gene encoding growth hormone receptor (GHR or GHBP) is localized on human chromosome 5p13.1-p12, with nine exons. It possesses a cytoplasmic and an extracellular domain for protein binding.
Physical form
GHBP was lyophilized from a concentrated (1 mg/ml) solution with 0.0045 mM NaHCO3.
Preparation Note
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile dH2O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.
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