SRP5024
EIF2AK3 (563-1115), active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
DKFZp781H1925, HRI, PEK, PERK, WRS
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
Product Name
EIF2AK3 (563-1115), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
recombinant
expressed in E. coli
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
15-21 nmol/min·mg
mol wt
~115 kDa
NCBI accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EIF2AK3(9451)
Physical form
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation Note
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Josef Neu
Gastroenterology and Nutrition null
Carsten Carlberg
Nutrigenomics null
Jaime D Blais et al.
Molecular and cellular biology, 24(17), 7469-7482 (2004-08-18)
Hypoxic stress results in a rapid and sustained inhibition of protein synthesis that is at least partially mediated by eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation by the endoplasmic reticulum (ER) kinase PERK. Here we show through microarray analysis of polysome-bound
H P Harding et al.
Molecular cell, 5(5), 897-904 (2000-07-06)
Malfolded proteins in the endoplasmic reticulum (ER) inhibit translation initiation. This response is believed to be mediated by increased phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) and is hypothesized to reduce the work load imposed on the folding machinery during
Identification of common variants influencing risk of the tauopathy Progressive Supranuclear Palsy
Gunter U
Nature Genetics (2011)
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