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Merck
CN

SRP5098

Sigma-Aldrich

ULK3, active, His tagged human

PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(s):

DKFZP434C131

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

Key Documents

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recombinant

expressed in baculovirus infected Sf9 cells

product line

PRECISIO® Kinase

Assay

≥70% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

195-265 nmol/min·mg

mol wt

~51 kDa

NCBI accession no.

BC157884

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... ULK3(25989)

General description

The ULK3 (unc-51 like kinase 3) gene is mapped to human chromosome 15q24.1.

Biochem/physiol Actions

ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. ULK3 participates in cell cycle checkpoint and prevents the progression of cell division prior to complete chromosome separation. Overexpression of ULK3 stimulates autophagy through fibroblast activation.

Physical form

Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.

Preparation Note

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Legal Information

PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Danger

Hazard Statements

H315,H319,H360D

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

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Certificates of Analysis (COA)

Lot/Batch Number
W030-2

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