SRP6162
FGF-8b human
recombinant, expressed in human cells, ≥95% (SDS-PAGE)
Synonym(s):
AIGF, FGF-17a, Fibroblast growth factor 17a, Fibroblast growth factor 8b, HBGF-8
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in human cells
Mol wt:
30-45 kDa (monomer, glycosylated)
biological source
human
recombinant
expressed in human cells
assay
≥95% (SDS-PAGE)
form
lyophilized
mol wt
30-45 kDa (monomer, glycosylated)
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FGF8(2253)
General description
FGF8 (fibroblast growth factor 8) is mapped to human chromosome 10q24.32. It is a part of the fibroblast growth factor family. In adults, the FGF8 gene is expressed only in testis. During development, FGF8a and FGF8b isoforms are expressed in midbrain and hindbrain.
Biochem/physiol Actions
FGF8 (fibroblast growth factor 8) gene encodes secreted signaling molecules, which is essential for the formation of face, brain and limbs, during development. Overexpression of FGF8 is observed in hepatocellular carcinoma and also offers resistance to chemotherapy. FGF family members have wide mitogenic and cell survival activities and participate in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF8 supports androgen and anchorage independent growth of mammary tumor cells. FGF8 over expression increases tumor growth and angiogensis. The adult expression of FGF-8 gene is restricted to testes and ovaries. FGF8 functions as an embryonic epithelial factor. FGF8 takes part in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination.
Physical form
Lyophilized in solution of 10 mM Tris-HCl, pH 7.4, with 800 mM NaCl
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile water containing 0.1% endotoxin-free recombinant human serum albumin.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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