SRP6309
Proteinase 3 from human neutrophils
≥95% (SDS-PAGE)
Synonym(s):
AGP7, C-ANCA antigen, Leukocyte proteinase 3, Neutrophil proteinase 4, P29, Wegener autoantigen
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About This Item
UNSPSC Code:
12352200
Form:
frozen liquid
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Mol wt:
29 kDa
biological source
human
assay
≥95% (SDS-PAGE)
form
frozen liquid
mol wt
29 kDa
packaging
pkg of 25 μg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... AGP7(5657)
General description
Proteinase 3 is one of the serine proteinases localized in azurophil granules of polymorphonuclear leukocytes. It has been identified as the autoantigen of Wegener granulomatosis, a systemic vasculitis complicated by melomonocyte proliferation. It exhibits proteolytic activity towards a range of substrates. It is physiologically inhibited by α1-antitrypsin. The protein has been described as having antibiotic and growth-promoting properties and causing emphysema when administered by tracheal insufflation. Proteinase 3 (PR-3) is also known as myeloblastin and p29b.
Physical form
Frozen in 50 mM MES, pH 4.5 with 700 mM NaCl.
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
高风险级别生物产品--人源产品
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