SRP6367
KLRK1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
CD314, D12S2489E, KLR, NKG2-D, NKG2-D type II integral membrane protein, NKG2D
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Biological source:
human
Recombinant:
expressed in E. coli
Assay:
≥90% (SDS-PAGE)
Form:
liquid
Mol wt:
19.2 kDa (168 aa, 73-216 aa + His Tag)
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
19.2 kDa (168 aa, 73-216 aa + His Tag)
packaging
pkg of 100 μg
concentration
0.5 mg/mL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... KLRK1(22914)
General description
KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Physical form
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Abbe N Vallejo et al.
PloS one, 6(10), e26558-e26558 (2011-10-27)
Exceptional aging has been defined as maintenance of physical and cognitive function beyond the median lifespan despite a history of diseases and/or concurrent subclinical conditions. Since immunity is vital to individual fitness, we examined immunologic fingerprint(s) of highly functional elders.
Oriane Cédile et al.
PloS one, 5(10), e13466-e13466 (2010-10-27)
RAE-1 is a ligand of the activating receptor NKG2D expressed by NK cells, NKT, γδT and some CD8(+)T lymphocytes. RAE-1 is overexpressed in tumor cell lines and its expression is induced after viral infection and genotoxic stress. We have recently
Vaihere Delaune et al.
Transplant international : official journal of the European Society for Organ Transplantation, 33(6), 675-688 (2020-02-01)
Intraportal islet transplantation is plagued by an acute destruction of transplanted islets. Amongst the first responders, NK cells and macrophages harbour an activating receptor, NKG2D, recognizing ligands expressed by stressed cells. We aimed to determine whether islet NKG2D ligand expression
Hanbyoul Cho et al.
BMC cancer, 14, 957-957 (2014-12-17)
NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and the heterogeneity of NKG2DL expression remains unclear. Here
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