SRP6367
KLRK1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
别名:
CD314, D12S2489E, KLR, NKG2-D, NKG2-D type II integral membrane protein, NKG2D
生物来源
human
重组
expressed in E. coli
方案
≥90% (SDS-PAGE)
表单
liquid
分子量
19.2 kDa (168 aa, 73-216 aa + His Tag)
包装
pkg of 100 μg
浓度
0.5 mg/mL
UniProt登记号
运输
dry ice
储存温度
−70°C
基因信息
human ... KLRK1(22914)
一般描述
KLRK1 is an activating receptor that has recently generated considerable interest. The most intriguing of these are a pair of closely related proteins called MICA and MICB. These are cell-surface molecules distantly related to MHC class I proteins, and the genes possess elements of heat shock promoters. MICA and MICB, therefore, are expressed during cell stress and are up-regulated in tumor cells and during viral infections. This receptor-ligand combination may play a critical role in the immune response to a variety of pathologies. Recombinant human KLRK1 protein, fused to His-tag at N-terminus, was expressed in E.coli.
外形
0.5 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Abbe N Vallejo et al.
PloS one, 6(10), e26558-e26558 (2011-10-27)
Exceptional aging has been defined as maintenance of physical and cognitive function beyond the median lifespan despite a history of diseases and/or concurrent subclinical conditions. Since immunity is vital to individual fitness, we examined immunologic fingerprint(s) of highly functional elders.
Vaihere Delaune et al.
Transplant international : official journal of the European Society for Organ Transplantation, 33(6), 675-688 (2020-02-01)
Intraportal islet transplantation is plagued by an acute destruction of transplanted islets. Amongst the first responders, NK cells and macrophages harbour an activating receptor, NKG2D, recognizing ligands expressed by stressed cells. We aimed to determine whether islet NKG2D ligand expression
Hanbyoul Cho et al.
BMC cancer, 14, 957-957 (2014-12-17)
NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and the heterogeneity of NKG2DL expression remains unclear. Here
Oriane Cédile et al.
PloS one, 5(10), e13466-e13466 (2010-10-27)
RAE-1 is a ligand of the activating receptor NKG2D expressed by NK cells, NKT, γδT and some CD8(+)T lymphocytes. RAE-1 is overexpressed in tumor cell lines and its expression is induced after viral infection and genotoxic stress. We have recently
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