SRP6399
IL-2 R beta/CD122 human
recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
Synonym(s):
IL2RB, P70-75, RP5-1170K4.6
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About This Item
UNSPSC Code:
12352202
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Assay:
≥90% (SDS-PAGE)
Form:
lyophilized
Mol wt:
calculated mol wt 25.4 kDa, observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
Impurities:
<1 EU/μg endotoxin (LAL test)
biological source
human
recombinant
expressed in HEK 293 cells
tag
6-His tagged (C-terminus)
assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
calculated mol wt 25.4 kDa, observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
packaging
pkg of 10 μg
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL2RB(3560)
General description
Interleukin-2 receptor (IL-2R)/ cluster of differentiation 122 (CD122) is a heterotrimeric protein, encoded by the gene mapped to human chromosome 22q12.3. The encoded protein is expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α subunit is involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. IL2R β is a member of the type I cytokine receptor family.
Application
Interleukin 2 receptor subunit β (IL2RB)/cluster of differentiation 122 (CD122) human has been used to study the effect of this cytokine on the expression of Klf15 in neurons.
Biochem/physiol Actions
Interleukin 2 receptor subunit β (IL2RB) is involved in signal transduction via its ligand interleukin-2. It is also implicated in inflammation. Cluster of differentiation 122 (CD122) is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.
Physical form
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions.
Sharon M, et al.
Science, 234(4778), 859-863 (1986)
Oxalate upregulates expression of IL-2Rβ and activates IL-2R signaling in HK-2 cells, a line of human renal epithelial cells.
Koul S, et al.
American Journal of Physiology: Renal Physiology, 306(9), F1039-F1046 (2014)
Abnormal expression pattern of the IL-2 receptor β-chain on CD4+ T cells in ANCA-associated vasculitis.
Wilde B, et al.
Disease Markers (2014)
Regulatory CD56bright natural killer cells mediate immunomodulatory effects of IL-2Rα-targeted therapy (daclizumab) in multiple sclerosis
Bielekova B, et al.
Proceedings of the National Academy of Sciences of the USA, 103(15), 5941-5946 (2006)
Cytokine receptor signaling through the Jak?Stat?Socs
pathway in disease.
pathway in disease.
Lynda A O, et al.
Molecular Immunology, 44, 2497-2506 (2007)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP6399-10UG | 04061837257490 |
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