SRP6426
E-Cadherin/ECAD/Cadherin-1/CD324 Protein human
recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
Synonym(s):
Arc-1, CDH1, LCAM, UVO
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human
Form:
lyophilized
Mol wt:
calculated mol wt 67 kDa, observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)
Assay:
≥90% (SDS-PAGE)
biological source
human
recombinant
expressed in HEK 293 cells
tag
6-His tagged (C-terminus)
sterility
sterile
assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
calculated mol wt 67 kDa, observed mol wt 67 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 23 is the predicted N-terminal.)
packaging
pkg of 25 μg
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CDH1(999)
General description
Cadherin-1 (CDH1) is a transmembrane protein, which is mainly involved in cell adhesion in normal epithelia. The associated gene is mapped to human chromosome 16q22.1.
Biochem/physiol Actions
Cadherin-1 (CDH1) stabilizes the cell adhesion in normal cells and also helps in signaling via association with β catenin. Mutations in the CDH1 gene are linked with oral clefts in the Thai population. CDH1 works as a tumor suppressor in various cancers. Low expression of CDH1 increases cellular invasive and metastatic potential. For instance, low expression of this gene is associated with poor survival of patients with esophageal cancer.
Physical form
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Assignment1 of the E-cadherin gene (CDH1) to chromosome 16q22.1 by radiation hybrid mapping.
Huntsman DG and Caldas C
Cytogenetics and Cell Genetics, 83, 82-82 (1998)
miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/?-Catenin and Notch-1/Akt Signaling Pathways.
Song H, et al.
International Journal of Molecular Sciences, 17, E1799-E1799 (2016)
Decreased expression of CDH1 or CTNNB1 affects poor prognosis of patients with esophageal cancer.
Ishiguro H, et al.
World Journal of Surgical Oncology, 14, 240-240 (2016)
Variants of the CDH1 (E-Cadherin) Gene Associated with Oral Clefts in the Thai Population.
Ittiwut R, et al.
Genetic Testing and Molecular Biomarkers, 20, 406-406 (2016)
Dapeng Sun et al.
PloS one, 17(9), e0274919-e0274919 (2022-09-23)
Aim to investigate the effect of miR-206 on the growth and metastasis of breast cancer stem cells and clarify the precise mechanism of miR-206 on EVI-1-mediated CALR expression in driving malignant phenotype. Our results showed that miR-206 mimics suppressed CALR
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