SRP6506
Haptoglobin Plasma (MixedType) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Bp, Haptoglobin b-Chain, Hp, haptoglobin a-chain
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
monomer 200 kDa (Hp 2-1), monomer 400 kDa (Hp 2-2), monomer 86 kDa (Hp 1-1)
General description
An acute-phase plasma protein found in human plasma at 100-300 mg/100 mL. Binds hemoglobin, thus preventing loss of iron through the kidneys. Humans are polymorphic for haptoglobin, with three major phenotypes: Hp 1-1, Hp 2-1, and Hp 2-2. While the phenotypic distribution can vary greatly between ethnicities and geographic location, the Hp 2-1 phenotype is the most prevalent phenotype in humans. Plasma concentrations of haptoglobin are highest in individuals with Hp 1-1, intermediate in Hp 2-1 individuals, and lowest in Hp 2-2 individuals. Hp 1-1 is the most effective at binding hemoglobin, and Hp 2-2 is the least effective. This functional difference may be associated with the frequency and severity of epilepsy attacks, as researchers have found a correlation between recurring seizures and the Hp 2-2 phenotype.
Physical form
Lyophilized as a salt-free solid.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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