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SRP6508

Haptoglobin (Phenotype 2-2) from human plasma

≥95% (SDS-PAGE)

Synonym(s):

Hp 2-2

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
170-900 kDa
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biological source

human plasma

assay

≥95% (SDS-PAGE)

form

lyophilized

mol wt

170-900 kDa

packaging

pkg of 1 mg

UniProt accession no.

P00738

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HP(3240)

General description

Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.

Application

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.

Biochem/physiol Actions

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.

Physical form

Lyophilized as a salt-free solid.

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

13 - Non Combustible Solids

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