SRP6508
Haptoglobin (Phenotype 2-2) from human plasma
≥95% (SDS-PAGE)
Synonym(s):
Hp 2-2
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Biological source:
human plasma
Assay:
≥95% (SDS-PAGE)
Form:
lyophilized
Mol wt:
170-900 kDa
General description
Haptoglobin(Hp) is an acute-phase antioxidant, found abundantly in the plasma , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2. The HP gene is mapped on the human chromosome at16q22.2.
Application
Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells. It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.
Biochem/physiol Actions
Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage. Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1. Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy. It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes. Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.
Physical form
Lyophilized as a salt-free solid.
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
13 - Non Combustible Solids
Regulatory Information
高风险级别生物产品--人源产品
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Haptoglobin 2-2 genotype determines chronic vasospasm after experimental subarachnoid hemorrhage
Chaichana K, et al.
Stroke, 38(12), 3266-3271 (2007)
The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness
Rinkoo D, et al.
Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease, 13(5), 373?376-373?376 (2016)
Trans-ethnic predicted expression genome-wide association analysis identifies a gene for estrogen receptor-negative breast cancer
Guimin G, et al.
PLoS Genetics (2017)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP6508-1MG | 04061837309007 |