SRP6526
FTO human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
FATSO, Fat Mass and Obesity-associated Protein
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Concentration:
0.2 mg/mL
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.)
packaging
pkg of 10 μg
concentration
0.2 mg/mL
impurities
<1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FTO(79068)
General description
The fat mass and obesity-associated (FTO) gene is mapped to human chromosome 16q12.2. The encoded protein is a nuclear protein and belongs to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family.
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.
Biochem/physiol Actions
FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans.
Physical form
0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.
Storage Class
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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