SRP6539
NQO1 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
Synonym(s):
Azoreductase, DT-Diaphorase (DTD), Dioxin-inducible 1, Disphorase-4 (DIA4), Menadione Reductase, NAD(P)H Dehydrogenase (Quinine) 1 (NQO1), NAD(P)H Quinone Oxireductase, Phylloquinone Reductase, Quinone Oxidoreductase 1, Quinone Reductase 1 (QR1)
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
biological source
human
recombinant
expressed in E. coli
assay
≥90% (SDS-PAGE)
form
liquid
mol wt
~30 kDa (Human NQO1 aa 1-274 is fused at the C-terminus to a His-tag.)
packaging
pkg of 10 and 50 μg
impurities
<0.1 EU/μg endotoxin (LAL test)
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NQO1(1728)
General description
Research area: Cell signaling. NQO1 (NAD(P)H quinone dehydrogenase 1) is an obligate two-electron reductase. It is a cytoplasmic, homodimeric protein, with one FAD molecule per monomer. This gene is localized to human chromosome 16q23. It shows a wide range of tissue expression.
Biochem/physiol Actions
NQO1 (NAD(P)H quinone dehydrogenase 1) uses NADH or NADPH as a reducing cofactor, and is characterized by its inhibition by dicoumarol. It is thought to confer protection against natural and exogenous quinones. It is involved in the conversion of benzene derived quinones to less toxic hydroquinones, and participates in benzene-associated hematotoxicity. It is involved in the reduction and eventual activation of few chemotherapeutic drugs and of environmental carcinogens, such as heterocyclic amines, nitroaromatic compounds, and possibly cigarette smoke particulate. C609T null variant of this gene is linked with breast cancer susceptibility in north Indian patients. NQO1 is up-regulated in serous ovarian carcinoma, and this expression is linked with poor prognosis; hence, this gene has potential as biomarker for the same.
Physical form
0.2 μm-filtered solution in 50 mM Tris-Cl, pH 8.0, containing 1 mM DTT.
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
signalword
Warning
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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High expression of NQO1 is associated with poor prognosis in serous ovarian carcinoma.
Cui X, et al.
BMC Cancer, 15:244 (2015)
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector.
Dinkova-Kostova AT and Talalay P.
Archives of Biochemistry and Biophysics, 501(1), 116-123 (2010)
Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia.
Larson RA, et al.
Blood, 94(2), 803-807 (1999)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP6539-50UG | 04061837310263 |
| SRP6539-10UG | 04061837310249 |