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SRP8001

Calreticulin human

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

Synonym(s):

CRP55, Calregulin, ERp60, Endoplasmic reticulum resident protein 60, grp60

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About This Item

NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
>90% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
~55 kDa by SDS-PAGE

Key Documents

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Product Name

Calreticulin human, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

biological source

human

recombinant

expressed in E. coli

tag

His tagged

assay

>90% (SDS-PAGE)

form

liquid

mol wt

~55 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

calcium flux assay: suitable

impurities

<1 EU/μg endotoxin, tested

UniProt accession no.

P27797

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CALR(811)

General description

Calreticulin (CALR) is expressed in the endoplasmic reticulum. The gene encoding it is localized on human chromosome 19p13.13.

Other Notes

Human calreticulin (aa18-417) is fused at the C-terminus to a His-tag.

Physical form

Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.

Application

Human calreticulin has been used in a study to determine the effects of uncoupling protein 4 (UCP4) on the expression of proteins in the store-operated Ca2+ entry pathway.

Biochem/physiol Actions

Calreticulin is involved in regulation of intracellular Ca2+ homoeostasis and ER Ca2+ capacity. It constitutes together with calnexin and ERp57 the ′calreticulin/calnexin cycle′ that is responsible for folding and quality control of newly synthesized glycoproteins. Calreticulin has been implicated to play a role in many biological systems, including functions inside and outside the ER, indicating that the protein is a multi-process molecule. Recently, Calreticulin was shown to enhance the merger of macrophages and tumor cells, increasing phagocytosis.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Lot/Batch Number
13290E8

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Calreticulin Is Involved in Invasion of Human Extravillous Trophoblasts Through Functional Regulation of Integrin ?1.
Yamamoto M
Endocrinology (2017)
CALR exon 9 mutations are somatically acquired events in familial cases of essential thrombocythemia or primary myelofibrosis
Elisa Rumi
Blood, 123 (2014)
Type 1 versus Type 2 calreticulin mutations in essential thrombocythemia: a collaborative study of 1027 patients
Ayalew Tefferi
American Journal of Hematology, 89 (2014)
New microdeletion and microduplication syndromes: a comprehensive review
Julian Nevado
Genetics and Molecular Biology (2014)
Mitochondrial Uncoupling Protein-4 Regulates Calcium Homeostasis and Sensitivity to Store Depletion-induced Apoptosis in Neural Cells*
Sic. L. Chan
The Journal of Biological Chemistry (2006)
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