SRP8003
Clusterin (nuclear form) mouse
>90% (SDS-PAGE), recombinant, expressed in E. coli, His tagged, liquid
Synonym(s):
Apolipoprotein J, CLI, Lymphocyte antigen 52 (Ly-52), SGP-2, TRPM-2
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Biological source:
mouse
Recombinant:
expressed in E. coli
Assay:
>90% (SDS-PAGE)
Form:
liquid
Mol wt:
~45 kDa by SDS-PAGE
Impurities:
<1 EU/μg endotoxin, tested
Product Name
Clusterin (nuclear form) mouse, recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)
biological source
mouse
recombinant
expressed in E. coli
tag
His tagged
assay
>90% (SDS-PAGE)
form
liquid
mol wt
~45 kDa by SDS-PAGE
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
concentration
≥0.2 mg/mL
impurities
<1 EU/μg endotoxin, tested
color
clear
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Clu(12759)
Biochem/physiol Actions
Clusterin is involved in tissue remodeling, cell death, lipid transport, complement-associated cell lysis, cancer and neurological damage. It is strongly expressed in Alzheimer′s and treatment-resistant cancer. High levels of clusterin are observed in ischemic heart disease and diabetic conditions. It also protects kidney from fibrosis. Nuclear form of clusterin works as a pro-death signal, and suppresses cell growth and survival. The secreted form of clusterin has extracellular chaperone and anti-apoptotic activities.
General description
Clusterin is expressed in all tissues. However, it is strongly expressed in the central nervous system and plasma. Clusterin mainly protects against heat and other stress. It is also referred as chaperone protein and stress-inducible biomarker. Clusterin exists in two isoforms, one is a secretory form and other is a nuclear form. The secreted form of the protein is a 80kDa disulfide-linked heterodimer of α and β subunits (produced by internal cleavage). The alternatively spliced inactive cytosolic form is changed to a truncated mature nuclear isoform via ionizing irradiation.
Other Notes
Mouse nuclear clusterin (aa 22-448) is fused at the C-terminus to a His-tag.
Physical form
Solution in 55 mM TRIS-HCl, pH 8.2, containing 150 mM NaCl.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Clusterin/apolipoprotein J attenuates angiotensin II-induced renal fibrosis.
Jung GS
PLoS ONE, 9, e105635-e105635 (2014)
Synthesis and functional analyses of nuclear clusterin, a cell death protein.
Leskov KS, et al.
The Journal of Biological Chemistry, 278, 11590-11590 (2003)
Ca2+ depletion induces nuclear clusterin, a novel effector of apoptosis in immortalized human prostate cells.
Caccamo AE, et al.
Cell Death and Differentiation, 12, 101-101 (2005)
Clusterin Modulates Allergic Airway Inflammation by Attenuating CCL20-Mediated Dendritic Cell Recruitment.
Hong GH, et al.
Journal of Immunology, 196, 2021-2021 (2001)
Clusterin is a potential lymphotoxin beta receptor target that is upregulated and accumulates in germinal centers of mouse spleen during immune response.
Afanasyeva MA, et al.
PLoS ONE, 9, e98349-e98349 (2014)
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