SRP8016
Progranulin mouse
>95% (SDS-PAGE), recombinant, expressed in HEK 293 cells,liquid, FLAG® tagged
Synonym(s):
PEPI, Proepithelin
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Biological source:
mouse
Recombinant:
expressed in HEK 293 cells
Assay:
>95% (SDS-PAGE)
Form:
liquid
Mol wt:
~70 kDa by SDS-PAGE
Impurities:
<0.1 EU/μg endotoxin, tested
Product Name
Progranulin mouse, recombinant, expressed in HEK 293 cells, FLAG® tagged, >95% (SDS-PAGE)
biological source
mouse
recombinant
expressed in HEK 293 cells
tag
FLAG® tagged
assay
>95% (SDS-PAGE)
form
liquid
mol wt
~70 kDa by SDS-PAGE
packaging
pkg of 10 μg
manufacturer/tradename
Sigma-Aldrich
storage condition
avoid repeated freeze/thaw cycles
concentration
≥0.2 mg/mL
impurities
<0.1 EU/μg endotoxin, tested
color
clear
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Grn(14824)
General description
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
Physical form
Solution in PBS.
Other Notes
Signal peptide and mouse progranulin (aa 1-589) are fused at the C-terminus to a FLAG®-tag.
Legal Information
FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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