SRP8023
PARG human
recombinant, expressed in Sf21 cells, His tagged, >95% (SDS-PAGE)
Synonym(s):
FNDC5 (cleaved), Poly(ADP-ribose) glycohydrolase
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About This Item
Form:
liquid
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in Sf21 cells
Mol wt:
~110 kDa by SDS-PAGE
biological source
human
recombinant
expressed in Sf21 cells
tag
His tagged
assay
>95% (SDS-PAGE)
form
liquid
mol wt
~110 kDa by SDS-PAGE
packaging
pkg of 2 μg
concentration
≥0.2 mg/mL
technique(s)
cell based assay: suitable
color
clear
solubility
water: soluble
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... PARG(8505)
General description
Research area: Cell signaling
Application
Biochem/physiol Actions
Poly(ADP-ribose) glycohydrolase(PARG) hydrolyzes poly(ADP-ribose) at glycosidic(1′′-2′′) linkage of ribose-ribose bond to produce free ADP-ribose. It is an endo- and exo-glycosidase. PARG plays arole in DNA repair and replication. Inhibited or depleted PARG in cells aremore prone to DNA-damaging agents. PARG also averts the accumulation of PAR inthe cytoplasm and parthanatos, a caspase-independent PAR-mediated type of celldeath.
Physical form
Solution in 50 mM TRIS-HCl, pH 7.5, containing 100 mM sodium chloride, 0.2% NP-40, 50 mM imidazole and 10% glycerol.
Other Notes
Human PARG is fused to a His-tag.
signalword
Danger
hcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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