SRP8028
DR6 (human): FC (human)
recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)
Synonym(s):
CD358, TNFRSF21, Tumor necrosis factor receptor superfamily member 21
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
biological source
human
recombinant
expressed in HEK 293 cells
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~80 kDa by SDS-PAGE
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TNFRSF21(27242)
General description
DR6 is an orphan TNF receptor superfamily member belonging to a subgroup of receptors called death receptors. Expressed ubiquitously with high expression in lymphoid organs, heart, brain, and pancreas. Broadly expressed by developing neurons where it functions as pro-apoptotic factor. Recently, it has been reported that interaction with the beta-amyloid precursor protein (APP) activates a widespread caspase-dependent self-destruction program dependent on caspase-6.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 50 μL deionized water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
Other Notes
The Fc portion of human IgG1 is fused to the C-terminus of human DR6 (aa 42-351).
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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