SRP8029
Flagellin from Salmonella typhimurium
>95% (SDS-PAGE)
Synonym(s):
FliC, Intelectin-1
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Form:
lyophilized
Assay:
>95% (SDS-PAGE)
Biological source:
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Mol wt:
~50 kDa by SDS-PAGE
biological source
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~50 kDa by SDS-PAGE
packaging
pkg of 10 μg
impurities
<0.01 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)
General description
The encoded flagellin filament contains 55 kDa monomers.
FliC (flagellin) is the subunit protein which polymerizes to form the filaments of bacterial flagella. The protein has four-domains (D0, D1, D2, D3).
Biochem/physiol Actions
FliC (flagellin) can activate the innate immune system by TLR5 (toll like receptor 5) and is an important proinflammatory molecule. FliC also induces the production of antibodies and is identified as an antigen by CD4+ T cells.
It also stimulates the production of proinflammatory mediators : nitric oxide, interleukin 1 (IL-1), IL-6, IL-8, and tumor necrosis factor α.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Zeng H, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko A N and Mizel S B
Infection and Immunity, 72(11), 6676-6679 (2004)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Cummings LA
Journal of Immunology, 174, 7929-7938 (2005)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRP8029-10UG | 04061837313806 |