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Safety Information

SRP8029

Sigma-Aldrich

Flagellin from Salmonella typhimurium

>95% (SDS-PAGE)

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Synonym(s):
FliC, Intelectin-1
CAS Number:
12777-81-0
NACRES:
NA.32

biological source

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2

Assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~50 kDa by SDS-PAGE

packaging

pkg of 10 μg

impurities

<0.01 EU/μg endotoxin, tested

color

white

UniProt accession no.

P06179

shipped in

wet ice

storage temp.

−20°C

Gene Information

Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)

General description

FliC (flagellin) is the subunit protein which polymerizes to form the filaments of bacterial flagella. The protein has four-domains (D0, D1, D2, D3).
The encoded flagellin filament contains 55 kDa monomers.

Biochem/physiol Actions

FliC (flagellin) can activate the innate immune system by TLR5 (toll like receptor 5) and is an important proinflammatory molecule. FliC also induces the production of antibodies and is identified as an antigen by CD4+ T cells.
It also stimulates the production of proinflammatory mediators : nitric oxide, interleukin 1 (IL-1), IL-6, IL-8, and tumor necrosis factor α.

Physical form

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Mucosal administration of flagellin induces innate immunity in the mouse lung.
Honko A N and Mizel S B
Infection and Immunity, 72(11), 6676-6679 (2004)
FliC-specific CD4+ T cell responses are restricted by bacterial regulation of antigen expression.
Cummings LA
Journal of Immunology, 174, 7929-7938 (2005)
Laís Rossi Perazza et al.
The Journal of nutrition, 150(10), 2673-2686 (2020-09-05)
Recent meta-analyses suggest that the consumption of fermented dairy products reduces type 2 diabetes and cardiovascular disease (CVD) risk, although the underlying mechanisms remain unclear. We evaluated whether dairy protein products modulated gut microbiota and cardiometabolic features in mouse models
In vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted.
Cummings LA
Molecular Microbiology, 61, 795-809 (2006)
Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways.
Zeng H, et al.
American Journal of Physiology: Gastrointestinal and Liver Physiology, 290(1), G96-G108 (2006)
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