SRP8030
Fn14 (human): FC (human)
recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)
Synonym(s):
CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A
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About This Item
UNSPSC Code:
51111800
NACRES:
NA.32
biological source
human
recombinant
expressed in HEK 293 cells
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~35 kDa by SDS-PAGE
packaging
pkg of 50 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.1 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TNFRSF12A(51330)
General description
TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 50 μL deionized water.
Other Notes
The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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