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Merck
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SRP8030

Fn14 (human): FC (human)

recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

Synonym(s):

CD266, E1A-associated protein p300, FGF-inducible 14, Tumor necrosis factor receptor superfamily member 12A

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About This Item

NACRES:
NA.32
UNSPSC Code:
51111800
Form:
lyophilized
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
~35 kDa by SDS-PAGE

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Product Name

Fn14 (human): FC (human), recombinant, expressed in HEK 293 cells, >95% (SDS-PAGE)

biological source

human

recombinant

expressed in HEK 293 cells

assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

~35 kDa by SDS-PAGE

packaging

pkg of 50 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.1 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q9NP84

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... TNFRSF12A(51330)

General description

TWEAK is a cytokine that controls proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK binds to Fn14, a highly inducible cell-surface receptor that is linked to several intracellular signalling pathways, including the nuclear factor-B (NF-kappaB) pathway. The TWEAK-Fn14 axis plays a beneficial role in tissue repair following acute injury and may contribute to cancer, chronic autoimmune diseases and acute ischaemic stroke.

Other Notes

The extracellular region of human FN14 (aa 28-75) is fused at the C-terminus to the Fc portion of human IgG1.

Physical form

Lyophilized from PBS.

Preparation Note

Reconstitute with 50 μL deionized water.

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
P20951010

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