SRP8035
IL-36α mouse
>95% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized
Synonym(s):
Interleukin-1 family member 6, Interleukin-1 homolog 1, Interleukin-1α, Interleukin-36α
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Product Name
IL-36α mouse, recombinant, expressed in E. coli, untagged, >95% (SDS-PAGE)
biological source
mouse
recombinant
expressed in E. coli
conjugate
untagged
Assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~17 kDa
packaging
pkg of 10 μg
impurities
<0.01 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
mouse ... Il36a(54448)
General description
IL-36α (IL-1F6), IL-36β (IL-1F8) and IL-36γ (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1β, IL-6, TNF-α and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Other Notes
IL-36alpha (mouse) (aa 8-160) is untagged.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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