SRP8040
LAG-3 (human): FC (human)
recombinant, expressed in CHO cells, >99% (SDS-PAGE)
Synonym(s):
FDC Protein, Lymphocyte activation gene-3, PC cell-derived growth factor
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
liquid
Assay:
>99% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in CHO cells
Mol wt:
~80 kDa by SDS-PAGE
biological source
human
recombinant
expressed in CHO cells
assay
>99% (SDS-PAGE)
form
liquid
mol wt
~80 kDa by SDS-PAGE
packaging
pkg of 50 μg
concentration
≥0.2 mg/mL
impurities
<0.1 EU/μg endotoxin, tested
color
clear
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... LAG3(3902)
General description
Biochem/physiol Actions
LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) both in vivo and in vitro. HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4+ and CD8+ T cells, and this is linked with disease progression. In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.
Physical form
Solution in PBS.
Other Notes
The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
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