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Merck
CN

SRP8044

CD40L, Soluble human

recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Synonym(s):

ACRP30headless:CD154, ACRP30headless:CD40L, ACRP30headless:TNFSF5, ADIPOQ-CD40L

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About This Item

NACRES:
NA.77
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
>95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in CHO cells
Mol wt:
35-40 kDa by SDS-PAGE
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biological source

human

recombinant

expressed in CHO cells

tag

FLAG® tagged

assay

>95% (SDS-PAGE)

form

lyophilized

mol wt

35-40 kDa by SDS-PAGE

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.01 EU/μg endotoxin, tested

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CD40LG(959)

General description

CD40L (cluster of differentiation 40 ligand) belongs to the tumor necrosis factor (TNF) family, and is expressed by basophils, B cells, monocytic cells, natural killer cells, platelets, mast cells and T cells. It is predominantly expressed on pro-inflammatory T cells. It also exists in a soluble form.

Biochem/physiol Actions

CD40L (cluster of differentiation 40 ligand) is active in its membrane-bound form. It interacts with CD40 and functions as a proinflammatory and procoagulant agent. The serum levels of soluble CD40L is elevated in malignant middle cerebral artery infarction (MMCAI) patients, especially in non-surviving patients.

Physical form

Lyophilized from PBS

Preparation Note

Reconstitute with 100 μL deionized water.

Other Notes

Human CD40L (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag.

Legal Information

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany


Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable



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