SRP8050
Profilin from Toxoplasma gondii
recombinant, expressed in E. coli, >95% (SDS-PAGE)
Synonym(s):
Inflammatory profilin, T Cell Membrane Protein 1
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
lyophilized
Assay:
>95% (SDS-PAGE)
Biological source:
Toxoplasma gondii
Recombinant:
expressed in E. coli
Mol wt:
~20 kDa by SDS-PAGE
biological source
Toxoplasma gondii
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE)
form
lyophilized
mol wt
~20 kDa by SDS-PAGE
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<0.01 EU/μg endotoxin, tested
color
white
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
Toxoplasma gondii ... PRF(7900190)
Biochem/physiol Actions
Profilin is a protozoan parasite protein. It activates toll-like receptor 11 (TLR11), which is an intracellular receptor localized on the endoplasmic reticulum (ER). TLR11 acts as an innate immune sensor for T. gondii profilin (TgPRF).The 12 membrane-spanning ER-resident protein UNC93B1 directly binds TLR11 and control the activation of dendritic cells in response to profilin (Toxoplasma gondii) and parasitic infection in vivo. TLR12 also has an ability to interact with (TgPRF). TLR12 is adequate for recognizing profilin in plasmacytoid dendritic cells (pDCs), whereas TLR11 and TLR12 are both needed in macrophages and conventional DCs. In contrast to TLR11, TLR12-deficient mice fail to resist T. gondii infection.
Physical form
Lyophilized from PBS.
Preparation Note
Reconstitute with 100 μL deionized water.
Other Notes
Recombinant profilin (Toxoplasma gondii) (aa 1-163).
Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Recognition of profilin by Toll-like receptor 12 is critical for host resistance to Toxoplasma gondii.
Koblansky A A, et al.
Immunity, 38(1), 119-130 (2013)
UNC93B1 is essential for TLR11 activation and IL-12 dependent host resistance to Toxoplasma Gondii.
Pifer R, et al.
The Journal of Biological Chemistry, M110-M110 (2010)
Erik W Martin et al.
Science signaling, 13(620) (2020-02-27)
The complex signaling dynamics of transcription factors can encode both qualitative and quantitative information about the extracellular environment, which increases the information transfer capacity and potentially supports accurate cellular decision-making. An important question is how these signaling dynamics patterns are
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