Skip to Content
Merck
CN

SRP8054

Tim-1 (human): FC (human)

recombinant, expressed in CHO cells, ≥98% (SDS-PAGE)

Synonym(s):

Hepatitis A virus cellular receptor 1, KIM1, T-cell immunoglobulin and mucin domain-containing protein 1, T-cell immunoglobulin and mucin domain-containing protein 4, TIMD1

Sign In to View Organizational & Contract Pricing

Select a Size

About This Item

UNSPSC Code:
12352200
NACRES:
NA.77

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

biological source

human

recombinant

expressed in CHO cells

Assay

≥98% (SDS-PAGE)

form

lyophilized

mol wt

monomer 57 kDa by calculation

packaging

pkg of 100 μg

storage condition

avoid repeated freeze/thaw cycles

impurities

<0.06 EU/μg endotoxin, tested

color

white

UniProt accession no.

Q96D42

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... HAVCR1(26762)

General description

The TIM (T cell/transmembrane, immunoglobulin and mucin) family plays a critical role in regulating immune responses, including allergy, asthma, transplant tolerance, autoimmunity and the response to viral infections. The unique structure of TIM immunoglobulin variable region domains allows highly specific recognition of phosphatidylserine (PtdSer), exposed on the surface of apoptotic cells. TIM-1 (T cell-immunoglobulinmucin; also KIM-1 and HAVcr-1) is a 100 kDa, type I transmembrane glycoprotein member of the TIM family of immunoglobulin superfamily molecules. There are two cytoplasmic alternate splice forms of TIM1. One is a long (359 aa) kidney form termed TIM-1b, and one is a short (334 aa) liver form termed TIM-1a. TIM-1, important for asthma and allergy, is preferentially expressed on T-helper 2 (Th2) cells and functions as a potent costimulatory molecule for T cell activation.

Physical form

Lyophilized from 0.2 μm-filtered solution in PBS.

Preparation Note

Reconstitute at 100 μg/mL in sterile PBS.

Other Notes

The extracellular domain of human Tim-1 (aa 21-295) is fused to the N-terminus of the Fc region of human IgG1.

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

新产品
This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
FT1504391
FT1202086
FT1109045

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service