SRP8059
Jagged-2 (human): FC (human)
recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)
Synonym(s):
Alpha-ketoglutarate-dependent dioxygenase FTO, Protein jagged-2, hJ2
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About This Item
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized
Assay:
≥90% (SDS-PAGE)
Recombinant:
expressed in HEK 293 cells
Mol wt:
~150 kDa by SDS-PAGE
recombinant
expressed in HEK 293 cells
assay
≥90% (SDS-PAGE)
form
lyophilized
mol wt
~150 kDa by SDS-PAGE
impurities
<0.1 EU/μgtested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... JAG2(3714)
General description
Jagged-2 is a putative Notch ligand involved in the mediation of Notch signaling, that can induce stromal cells to secrete IL-6, VEGF and IGF-1. Notch activation can interact with NF-kappaB and C-myc to promote the proliferation and to inhibit the apoptosis of MM cells, showing in the relationship between the incidence of myeloma and drug resistance. Jagged-2 is also involved in limb development.
Physical form
Lyophilized. Contains PBS + 0.02 % CHAPS.
Preparation Note
Reconstitute with 100μl sterile water.
Other Notes
Human Jagged-2 (aa 1-1054) is fused at the C-terminus to the Fc portion of human IgG.
Storage Class
12 - Non Combustible Liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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