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T0512

Taurolithocholic acid 3-sulfate disodium salt

Name: Taurolithocholic acid 3-sulfate disodium salt
Brand: SIGMA

Synonym(s):

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide 3-sulfate

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About This Item

Linear Formula:

C₂₆H₄₃NO₈S₂Na₂

CAS Number:

64936-83-0

Molecular Weight:

607.73

NACRES:

NA.25

PubChem Substance ID:

24899892

UNSPSC Code:

12161900

MDL number:

MFCD00055891

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description

anionic

Quality Level

200

assay

≥90.0% (TLC)

mol wt

607.73 g/mol

impurities

≤3% (TLC)

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](C2)OS(O)(=O)=O

InChI

1S/C26H45NO8S2.Na.H/c1-17(4-9-24(28)27-14-15-36(29,30)31)21-7-8-22-20-6-5-18-16-19(35-37(32,33)34)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23H,4-16H2,1-3H3,(H,27,28)(H,29,30,31)(H,32,33,34);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

InChI key

POWDNUISUWSLLN-RLHFEMFKSA-N

Related Categories

Biochemicals

Detergents - Anionic, Cationic, Zwitterionic, Anti-foaming

General description

Taurolithocholic acid 3-sulfate disodium salt is a natural detergent bile salt with potential use as a topical microbicidal agent.

Application

Taurolithocholic acid 3-sulfate disodium salt has been used in a study to assess the electrophysiological effects of bile acids on pancreatic acinar cells. It has also been used in a study to investigate the mechanisms underlying the inhibition of bile acid-induced apoptosis by cyclic AMP in rat hepatocytes.

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Bile acids induce a cationic current, depolarizing pancreatic acinar cells and increasing the intracellular Na+ concentration.

Svetlana G Voronina et al.

The Journal of biological chemistry, 280(3), 1764-1770 (2004-11-13)

Biliary disease is a major cause of acute pancreatitis. In this study we investigated the electrophysiological effects of bile acids on pancreatic acinar cells. In perforated patch clamp experiments we found that taurolithocholic acid 3-sulfate depolarized pancreatic acinar cells. At

Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms

Graf, D., et al.

Archives of Biochemistry and Biophysics, 415, 9-9 (2003)

Chaiqin chengqi decoction alleviates severity of acute pancreatitis via inhibition of TLR4 and NLRP3 inflammasome: Identification of bioactive ingredients via pharmacological sub-network analysis and experimental validation.

Yongjian Wen et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 79, 153328-153328 (2020-10-03)

Chaiqin chengqi decoction (CQCQD) is a Chinese herbal formula derived from dachengqi decoction. CQCQD has been used for the management of acute pancreatitis (AP) in the West China Hospital for more than 30 years. Although CQCQD has a well-established clinical

Bile salts: natural detergents for the prevention of sexually transmitted diseases.

B C Herold et al.

Antimicrobial agents and chemotherapy, 43(4), 745-751 (1999-04-02)

The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens

Hepatocyte IKK2 protects Mdr2-/- mice from chronic liver failure.

Hanno Ehlken et al.

PloS one, 6(10), e25942-e25942 (2011-10-25)

Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2(-/-)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgene in

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Global Trade Item Number

SKU	GTIN
T0512-10MG	04061833613658

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