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CN

T0512

Taurolithocholic acid 3-sulfate disodium salt

Synonym(s):

3α-Hydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide 3-sulfate

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About This Item

Linear Formula:
C26H43NO8S2Na2
CAS Number:
64936-83-0
Molecular Weight:
607.73
NACRES:
NA.25
PubChem Substance ID:
24899892
UNSPSC Code:
12161900
MDL number:
MFCD00055891

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InChI

1S/C26H45NO8S2.Na.H/c1-17(4-9-24(28)27-14-15-36(29,30)31)21-7-8-22-20-6-5-18-16-19(35-37(32,33)34)10-12-25(18,2)23(20)11-13-26(21,22)3;;/h17-23H,4-16H2,1-3H3,(H,27,28)(H,29,30,31)(H,32,33,34);;/t17-,18-,19-,20+,21-,22+,23+,25+,26-;;/m1../s1

SMILES string

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCCS(O)(=O)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@H](C2)OS(O)(=O)=O

InChI key

POWDNUISUWSLLN-RLHFEMFKSA-N

description

anionic

assay

≥90.0% (TLC)

mol wt

607.73 g/mol

impurities

≤3% (TLC)

Quality Level

200

Related Categories

Application

Taurolithocholic acid 3-sulfate disodium salt has been used in a study to assess the electrophysiological effects of bile acids on pancreatic acinar cells. It has also been used in a study to investigate the mechanisms underlying the inhibition of bile acid-induced apoptosis by cyclic AMP in rat hepatocytes.

General description

Taurolithocholic acid 3-sulfate disodium salt is a natural detergent bile salt with potential use as a topical microbicidal agent.

wgk

WGK 3

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000497166
0000497166
0000443936
0000443936
0000415167

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Svetlana G Voronina et al.
The Journal of biological chemistry, 280(3), 1764-1770 (2004-11-13)
Biliary disease is a major cause of acute pancreatitis. In this study we investigated the electrophysiological effects of bile acids on pancreatic acinar cells. In perforated patch clamp experiments we found that taurolithocholic acid 3-sulfate depolarized pancreatic acinar cells. At
Inhibition of taurolithocholate 3-sulfate-induced apoptosis by cyclic AMP in rat hepatocytes involves protein kinase A-dependent and -independent mechanisms
Graf, D., et al.
Archives of Biochemistry and Biophysics, 415, 9-9 (2003)
B C Herold et al.
Antimicrobial agents and chemotherapy, 43(4), 745-751 (1999-04-02)
The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens
Yongjian Wen et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 79, 153328-153328 (2020-10-03)
Chaiqin chengqi decoction (CQCQD) is a Chinese herbal formula derived from dachengqi decoction. CQCQD has been used for the management of acute pancreatitis (AP) in the West China Hospital for more than 30 years. Although CQCQD has a well-established clinical
Hanno Ehlken et al.
PloS one, 6(10), e25942-e25942 (2011-10-25)
Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2(-/-)) develop chronic periductular inflammation and cholestatic liver disease resulting in the development of hepatocellular carcinoma (HCC). Inhibition of NF-κB by expression of an IκBα super-repressor (IκBαSR) transgene in
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