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T0632

Sodium thioglycolate

≥96.5% (iodometric)

Synonym(s):

Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt

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About This Item

Linear Formula:
HSCH2COONa
CAS Number:
367-51-1
Molecular Weight:
114.10
UNSPSC Code:
12352201
NACRES:
NA.25
PubChem Substance ID:
24899901
EC Number:
206-696-4
Beilstein/REAXYS Number:
4569109
MDL number:
MFCD00043386
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Quality Level

200

assay

≥96.5% (iodometric)

form

powder

color

white to off-white

useful pH range

6.7 (20 °C, 100 g/L)

mp

>300 °C (lit.)

solubility

water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)

storage temp.

−20°C

SMILES string

[Na+].[O-]C(=O)CS

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

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Application

Sodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Disclaimer

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Aquatic Chronic 3 - Met. Corr. 1 - Skin Sens. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SDBB8178
SDBB8181
SDBB8180
SDBB8173
SDBB4587

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PeerJ, 7, e6293-e6293 (2019-02-01)
Undigestible, insoluble food particles, such as wheat bran, are important dietary constituents that serve as a fermentation substrate for the human gut microbiota. The first step in wheat bran fermentation involves the poorly studied solubilization of fibers from the complex
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Berggaard N, et al.
eNeuro, 5(3) (2018)
Improved stability of recombinant hemagglutinin using a formulation containing sodium thioglycolate
Rhodes DG, et al.
Vaccine, 33(44), 6011-6016 (2015)
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Related Content

Product Information Sheet - T0632

Product Information Sheet

Global Trade Item Number

SKUGTIN
T0632-500G04061835367993
T0632-100G04061835367979
T0632-25G04061835367986

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