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T0632

Sigma-Aldrich

Sodium thioglycolate

≥96.5% (iodometric)

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Synonym(s):
Mercaptoacetic acid sodium salt, Thioglycolic acid sodium salt
Linear Formula:
HSCH2COONa
CAS Number:
367-51-1
Molecular Weight:
114.10
Beilstein:
4569109
EC Number:
206-696-4
MDL number:
MFCD00043386
PubChem Substance ID:
24899901
NACRES:
NA.25

Assay

≥96.5% (iodometric)

form

powder

color

white to off-white

useful pH range

6.7 (20 °C, 100 g/L)

mp

>300 °C (lit.)

solubility

water: ~609.1 g/L at 20 °C (OECD Test Guideline 105)

storage temp.

−20°C

SMILES string

[Na+].[O-]C(=O)CS

InChI

1S/C2H4O2S.Na/c3-2(4)1-5;/h5H,1H2,(H,3,4);/q;+1/p-1

InChI key

GNBVPFITFYNRCN-UHFFFAOYSA-M

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Application

Sodium thioglycolate has been used:
  • as a growth supplement in enrichment media and to study its effect on Arcobacter
  • in influenza hemagglutinin formulation in order to reduce disulfide-mediated cross-linking and early potency loss
  • in electron microscopy

Biochem/physiol Actions

Sodium thioglycolate acts as reducing agent and is suitable for anaerobic and microaerophilic bacterial growth.
Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo.

Caution

At room temperature, concentrations over 70% in water tend to form 1-2% thioglycolides per month which hydrolyze to the original free compound when made acidic or alkaline. The 70% solution oxidizes in air but is stable at room temperature when tightly closed. Thioglycolate salts may also lose purity on storage. The exclusion of air does not materially improve stability.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

CorrosionSkull and crossbones
GHS05,GHS06

Signal Word

Danger

Hazard Statements

H290 - H301 - H312 - H317

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Met. Corr. 1 - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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