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T0909

Tenoxicam

Name: Tenoxicam
Brand: SIGMA

NSAID

Synonym(s):

4-Hydroxy-2-methyl-N-2-pyridinyl-2H-thieno(2,3-e)-1,2-thiazine-3-carboxamide 1,1-dioxide

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₁N₃O₄S₂

CAS Number:

59804-37-4

Molecular Weight:

337.37

NACRES:

NA.77

PubChem Substance ID:

24899922

UNSPSC Code:

12352202

MDL number:

MFCD00083502

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Quality Level

100

assay

≥98% (perchloric acid titration)

form

powder

solubility

DMF: 25 mg/mL, clear, yellow-green

SMILES string

O=C(NC1=NC=CC=C1)C2=C(O)C(SC=C3)=C3S(N2C)(=O)=O

InChI

1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)

InChI key

LZNWYQJJBLGYLT-UHFFFAOYSA-N

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Related Categories

Bioactive Small Molecule Inhibitors

Application

Tenoxicam has been used:

as a non-steroidal anti-inflammatory agent (NSAID) to study its effects on root gravitropism in Arabidopsis thaliana
as a standard in microanalysis of NSAIDs by spectrophotometry
to test its effect on surface potential andmembrane fluidity modification in phosphoglyceride monolayers

Biochem/physiol Actions

Non-steroidal antiinflammatory drug (NSAID) with comparatively low risk of renal or hepatic toxicity.

Tenoxicam (TX) possesses antipyretic and analgesic effects. It elicits radical scavenging activity and has the potential to treat enkylosing spondylitis, extra-articular diseases, acute gout, and rheumatic diseases. It is also effective in treating primary dysmenorrhea, postpartum uterine contraction pain, and post-operation backaches. TX is capable of inhibiting prostaglandin synthesis.

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of tenoxicam through hairless mouse skin.

Hye Sun Gwak et al.

International journal of pharmaceutics, 236(1-2), 57-64 (2002-03-14)

The effects of vehicles and penetration enhancers on the in vitro permeation of tenoxicam from saturated solutions through dorsal hairless mouse skin were investigated. Various types of vehicles, including ester-, alcohol-, and ether-types and their mixtures, were used as vehicles

Differentiating oxicam nonsteroidal anti-inflammatory drugs in phosphoglyceride monolayers.

Katarzyna Czapla et al.

Langmuir : the ACS journal of surfaces and colloids, 26(5), 3485-3492 (2009-12-25)

Meloxicam, piroxicam, and tenoxicam belong to a highly potent oxicam group of nonsteroidal anti-inflammatory drugs. Whereas the structurally similar oxicams have different pharmacokinetics, treatment efficiency, and adverse effects, their common mechanism of action is the inhibition of a membrane enzyme

Microanalysis of Selected NSAIDs Using the Spectrophotometric Method

Gumulka P, et al.

Engineering and Technology, 1(2), 211-221 (2020)

Clinical pharmacokinetics of tenoxicam.

O G Nilsen

Clinical pharmacokinetics, 26(1), 16-43 (1994-01-01)

Tenoxicam is a nonsteroidal anti-inflammatory drug (NSAID) in the oxicam group. It is completely absorbed by the oral route and is about 99% protein bound in human plasma. Intake of food delays absorption without affecting bioavailability. There is no evidence

Tenoxicam. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.

J P Gonzalez et al.

Drugs, 34(3), 289-310 (1987-09-01)

Tenoxicam is a new non-steroidal anti-inflammatory and analgesic agent of the oxicam class, and therefore closely related to piroxicam. It possesses a long half-life which enables it to be administered once daily. Clinical trials in patients with rheumatoid arthritis, osteoarthritis

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Global Trade Item Number

SKU	GTIN
T0909-5G	04061832949611
T0909-250MG	04061837336133
T0909-1G	04061826739938

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