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Merck
CN

T1016

Trichlormethiazide

≥98%

Synonym(s):

6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
(+/-)-, NSC 61560

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About This Item

Empirical Formula (Hill Notation):
C8H8Cl3N3O4S2
CAS Number:
133-67-5
Molecular Weight:
380.66
NACRES:
NA.25
PubChem Substance ID:
24899924
UNSPSC Code:
12352200
EC Number:
205-118-8
MDL number:
MFCD00057315

Key Documents

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InChI key

LMJSLTNSBFUCMU-UHFFFAOYSA-N

InChI

1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

SMILES string

NS(=O)(=O)c1cc2c(NC(NS2(=O)=O)C(Cl)Cl)cc1Cl

assay

≥98%

Quality Level

100

Gene Information

human ... SLC12A3(6559)

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H317,H334

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCBP8847V
BCBP8847
BCBP7836
BCBP4919
BCBN5940

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Takashi Uzu et al.
Journal of hypertension, 23(4), 861-865 (2005-03-19)
We examined whether thiazide diuretics could restore nocturnal blood pressure (BP) decline and reduce urinary protein excretion in patients with glomerulopathy treated with angiotensin II modulators (angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers). Twenty-five Japanese outpatients (11 men, 14
Susumu Ogawa et al.
Hypertension (Dallas, Tex. : 1979), 47(4), 699-705 (2006-03-01)
We tested the hypothesis that blockade of angiotensin II type 1 receptors reduces oxidative stress markers in parallel with urinary albumin and type IV collagen excretions. Sixty-six diabetic patients with nephropathy were randomly assigned to either the angiotensin II receptor
Kenichiro Miura et al.
Pediatric nephrology (Berlin, Germany), 24(6), 1235-1238 (2009-01-21)
The administration of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin type 1 receptor blockers (ARBs) to pregnant women has been reported to cause ACEI/ARB fetopathy, including oligohydramios, pulmonary hypoplasia, renal insufficiency, limb contracture, and fetal hypotension in the child. Most of
Karen Menuz et al.
Science (New York, N.Y.), 318(5851), 815-817 (2007-11-03)
Quinoxalinedione compounds such as 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) are the most commonly used alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonists. However, we find that in the presence of transmembrane AMPA receptor regulatory proteins (TARPs), which are AMPA receptor auxiliary subunits, CNQX acts as a
Toshihiko Ishimitsu et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 32(11), 962-968 (2009-08-22)
To achieve the target blood pressure recommended by the latest guidelines, multiple antihypertensive drugs are needed in most patients. In this study, the efficacy of treatment using an angiotensin II receptor antagonist (ARB) combined with a calcium channel blocker (CCB)
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