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T104

Tropisetron monohydrochloride

Name: Tropisetron monohydrochloride
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride, 3-Tropanylindole-3-carboxylate monohydrochloride, ICS-205,930, Navoban

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₀N₂O₂ · HCl

CAS Number:

105826-92-4

Molecular Weight:

320.81

NACRES:

NA.77

PubChem Substance ID:

24278133

UNSPSC Code:

12352200

MDL number:

MFCD00210221

Assay:

≥98% (HPLC)

Form:

solid

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assay

≥98% (HPLC)

form

solid

solubility

H₂O: >10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34

InChI

1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H

InChI key

XIEGSJAEZIGKSA-UHFFFAOYSA-N

Gene Information

human ... CHRNA3(1136), CHRNA4(1137), CHRNB2(1141), CHRNB4(1143), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242)
rat ... Chrna7(25302), Drd2(24318), Htr1a(24473), Htr3a(79246)

Application

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

Biochem/physiol Actions

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

Features and Benefits

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat.

Q Pei et al.

European journal of pharmacology, 230(1), 63-68 (1993-01-05)

The effects of three different 5HT3 receptor antagonists, granisetron, ICS 205-930 and ondansetron (0.01, 0.1 and 1 mg/kg, s.c.) were tested on changes in mesolimbic dopamine function produced by 1 mg/kg of morphine in the rat. Increases of in vivo

Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs.

N Yoshida et al.

The Journal of pharmacology and experimental therapeutics, 256(1), 272-278 (1991-01-01)

We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During the digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect GI motor activity at

Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum.

E Beubler et al.

European journal of pharmacology, 248(2), 157-162 (1993-08-02)

The effects of cholera toxin and heat stable Escherichia coli (E. coli) enterotoxin on intestinal fluid secretion are commonly considered to be mediated by cyclic nucleotides. It was demonstrated recently, by using the 5-hydroxytryptamine (5-HT)2 receptor antagonist ketanserin and the

Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study.

Li Yu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 846(1-2), 20-23 (2006-09-12)

A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C(8) reversed column using a mixture of ammonium acetate (100 mM

Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice.

Orie Tomoyose et al.

Journal of pharmacological sciences, 126(2), 136-145 (2014-09-26)

Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell recordings were made from dorsal horn

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Global Trade Item Number

SKU	GTIN
T104-50MG	04061832086194

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