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T111000

DMT-dT Phosphoramidite

Synonym(s):

5′-O-(4,4′-dimethoxytrityl)-2′-deoxythymidine-3′-O-[O-(2-cyanoethyl)-N,N′-diisopropylphosphoramidite], 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-deoxythymidine, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite], DMT-dT amidite, Thymidine, 5′-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3′-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite]

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About This Item

Empirical Formula (Hill Notation):
C40H49N4O8P
CAS Number:
98796-51-1
Molecular Weight:
744.81
NACRES:
NA.51
PubChem Substance ID:
329826641
UNSPSC Code:
41116107
MDL number:
MFCD00055063
Assay:
≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)
Biological source:
non-animal source
Form:
powder or granules
Solubility:
water: soluble 0.00051 g/L at 20 °C
Storage temp.:
2-8°C
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biological source

non-animal source

Quality Segment

200

type

for DNA synthesis

product line

Proligo Reagents

assay

≥99% (31P-NMR), ≥99.0% (reversed phase HPLC)

form

powder or granules

technique(s)

oligo synthesis: suitable

impurities

≤0.3 wt. % water content (Karl Fischer)

color

white to off-white

solubility

water: soluble 0.00051 g/L at 20 °C

λ

conforms (UV/VIS Identity)

nucleoside profile

base: deoxythymidine
base protecting group: none
2' protecting group: none
5' protecting group: DMT
deprotection: fast/standard

storage temp.

2-8°C

SMILES string

COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C=C(C)C(=O)NC3=O)(c4ccccc4)c5ccc(OC)cc5

InChI

1S/C40H49N4O8P/c1-27(2)44(28(3)4)53(50-23-11-22-41)52-35-24-37(43-25-29(5)38(45)42-39(43)46)51-36(35)26-49-40(30-12-9-8-10-13-30,31-14-18-33(47-6)19-15-31)32-16-20-34(48-7)21-17-32/h8-10,12-21,25,27-28,35-37H,11,23-24,26H2,1-7H3,(H,42,45,46)/t35-,36+,37+,53?/m0/s1

InChI key

UNOTXUFIWPRZJX-CEXSRUIHSA-N

General description

DMT-dT Phosphoramidite belongs to the DNA Phosphoramidites group. Some key features of standard protected DNA phosphoramidite are mentioned below:
  • Exocyclic amine functions are protected by a benzoyl group (dA(bz) anddC(bz)) or isobutyryl group (dG(ib))
  • Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
  • The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides

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