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T122

Telenzepine dihydrochloride hydrate

Name: Telenzepine dihydrochloride hydrate
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

4,9-Dihydro-3-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₂N₄O₂S · 2HCl · xH₂O

CAS Number:

147416-96-4

Molecular Weight:

443.39 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

24277875

UNSPSC Code:

12352200

MDL number:

MFCD11045947

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

H₂O: >10 mg/mL

SMILES string

O.Cl.Cl.CN1CCN(CC1)CC(=O)N2c3ccccc3NC(=O)c4csc(C)c24

InChI

1S/C19H22N4O2S.2ClH.H2O/c1-13-18-14(12-26-13)19(25)20-15-5-3-4-6-16(15)23(18)17(24)11-22-9-7-21(2)8-10-22;;;/h3-6,12H,7-11H2,1-2H3,(H,20,25);2*1H;1H2

InChI key

HZWCRPGARSMPNS-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

Application

Telenzepine dihydrochloride hydrate was used to study M₁ muscarinic receptor-mediated signaling in juvenile rat hippocampus and rat urinary bladder.

Biochem/physiol Actions

Telenzepine is an analog of pirenzepine and inhibits the secretion of gastric acid. It is an antagonist to M₁-receptor and targets the oxyntic gastric glands and the salivary glands.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Gastric antisecretory activity of telenzepine, a new M1-selective muscarinic antagonist: comparison with pirenzepine.

G Coruzzi et al.

Archives internationales de pharmacodynamie et de therapie, 302, 232-241 (1989-11-01)

The new M1-receptor antagonist telenzepine has been studied for its antisecretory effect in different in vitro and in vivo experimental models in comparison with pirenzepine. Telenzepine was found to be from 3 to 10 times more potent than pirenzepine in

Pharmacological differentiation of presynaptic M1 muscarinic receptors modulating acetylcholine release from postsynaptic muscarinic receptors in guinea-pig ileum.

K Kawashima et al.

General pharmacology, 21(1), 17-21 (1990-01-01)

1. Effects of three muscarinic antagonists on electrically evoked ACh release and contractile response were investigated in longitudinal muscle strips of guinea-pig ileum suspended in an organ-bath and superfused with Krebs solution. ACh release was determined by a specific radioimmunoassay.

Control of gastric acid secretion by histamine H2 receptor antagonists and anticholinergics.

G Bertaccini et al.

Pharmacological research, 21(4), 339-352 (1989-07-01)

The control of gastric secretion may be obtained by means of several pharmacological compounds: histamine H2 receptor antagonists and anticholinergics are so far the most widely employed drugs in pharmacological experiments and in clinical practice. The H2 blockers are able

Increased density of M1 receptors in the hippocampus of juvenile rats chronically deprived of NGF.

A M Rosati et al.

Brain research, 815(2), 185-191 (1999-01-08)

Binding studies were used to assess the changes in affinity and/or number of M1 muscarinic receptors in hippocampi from juvenile rats chronically deprived of NGF. NGF deprivation was obtained by implanting into right ventricle at postnatal day 2 (P2) hybrydoma

M(1) and M(3) muscarinic receptors are involved in the release of urinary bladder-derived relaxant factor.

Turgut Emrah Bozkurt et al.

Pharmacological research, 59(5), 300-305 (2009-05-07)

We have investigated the muscarinic receptor subtype(s) mediating the release of urinary bladder-derived relaxant factor that is demonstrated by a coaxial bioassay system. Acetylcholine-induced relaxation of a precontracted anococcygeus muscle mounted within the bladder was considered as an evidence for

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Global Trade Item Number

SKU	GTIN
T122-25MG	04061832093819
T122-100MG	04061832093796
T122-10MG	04061832093802

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