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T123

Thioperamide maleate salt

Name: Thioperamide maleate salt
Brand: SIGMA

≥98% (HPLC), histamine H3 receptor antagonist, solid

Synonym(s):

MR-12842, N-Cyclohexyl-4-(1H-imidazol-4-yl)-1-piperidinecarbothioamide maleate salt

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₂₄N₄S · C₄H₄O₄

CAS Number:

148440-81-7

Molecular Weight:

408.52

UNSPSC Code:

12352200

PubChem Substance ID:

24277809

NACRES:

NA.77

MDL number:

MFCD00083209

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

200

Storage condition:

desiccated, under inert gas

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Properties

Product Name

Thioperamide maleate salt, solid

assay

≥98% (HPLC)

Quality Level

200

form

solid

storage condition

desiccated, under inert gas

color

white

solubility

H₂O: >10 mg/mL, DMSO: 12 mg/mL, ethanol: 3 mg/mL

SMILES string

OC(=O)\C=C/C(O)=O.S=C(CC1CCCCC1)N2CCC(CC2)c3c[nH]cn3

InChI

1S/C16H25N3S.C4H4O4/c20-16(10-13-4-2-1-3-5-13)19-8-6-14(7-9-19)15-11-17-12-18-15;5-3(6)1-2-4(7)8/h11-14H,1-10H2,(H,17,18);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

REZRBLGMJZZSID-BTJKTKAUSA-N

Gene Information

human ... HRH3(11255)

Description

Application

Thioperamide maleate salt was used to study the sympathetic and autonomic nerve activity in mammalian white adipose tissue.

Biochem/physiol Actions

Potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier.

Thioperamide is a potent and selective H₃ histamine receptor antagonist that crosses the blood-brain barrier. It affects the central histaminergic system and decreases the duration of seizures and convulsions in mice. It also improves learning deficit induced by other drugs such as scopolamine.

Features and Benefits

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Effects of thioperamide, a histamine H3-receptor antagonist, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice.

S Miyazaki et al.

Life sciences, 57(23), 2137-2144 (1995-01-01)

We examined the effects of thioperamide and (R)-alpha-methylhistamine, a histamine H3-receptor antagonist and an agonist, respectively, on a scopolamine-induced learning deficit using an elevated plus-maze test in mice. Thioperamide alone slightly improved the learning deficit induced by scopolamine, and pretreatment

Regulation of sympathetic nerve activity by L-carnosine in mammalian white adipose tissue.

Jiao Shen et al.

Neuroscience letters, 441(1), 100-104 (2008-07-05)

Previously, we showed that l-carnosine, a bioactive dipeptide, influences the sympathetic nerve activity innervating kidney and brown adipose tissue. Because the autonomic nervous system plays an important role in the regulation of lipid metabolism, we investigated the in vivo effects

Histamine H

Hiroki Takei et al.

Frontiers in neural circuits, 11, 85-85 (2017-11-25)