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Merck
CN

T1330

Tamsulosin hydrochloride

≥98% (HPLC)

Synonym(s):

5-[(2R)-2-[[2-(2-Ethoxyphenoxy)ethyl]amino]propyl]-2-methoxybenzenesulfonamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C20H28N2O5S · HCl
CAS Number:
106463-17-6
Molecular Weight:
444.97
NACRES:
NA.77
PubChem Substance ID:
329826665
UNSPSC Code:
12352200
MDL number:
MFCD00922997

Key Documents

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Product Name

Tamsulosin hydrochloride, ≥98% (HPLC)

InChI

1S/C20H28N2O5S.ClH/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24;/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24);1H/t15-;/m1./s1

SMILES string

Cl.CCOc1ccccc1OCCN[C@H](C)Cc2ccc(OC)c(c2)S(N)(=O)=O

InChI key

ZZIZZTHXZRDOFM-XFULWGLBSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL

originator

Boehringer Ingelheim

storage temp.

room temp

Quality Level

100

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Biochem/physiol Actions

Tamsulosin is a α1A/1D-adrenoceptor antagonist; Used as a treatment of BPH (benign prostatic hypertrophy).
Tamsulosin is an α1A/1D-adrenoceptor antagonist used as a treatment of benign prostatic hypertrophy (BPH). Its activity as an ? blocker also affects the iris, and has led to complications during cataract surgery, a condition called "floppy iris" syndrome.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000514321
0000514321
0000457663
0000457663
0000118898

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Grzegorz Niemczyk et al.
BioMed research international, 2020, 6632359-6632359 (2021-01-01)
Bladder outlet obstruction (BOO) occurs in more than 20 percent of the adult population and may lead to changes in the structure and function of the bladder. The main objective of the study was to evaluate the expression of Toll-like
Shuo Yang et al.
The AAPS journal, 16(4), 860-871 (2014-05-31)
Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron
Nannan Chu et al.
Clinical therapeutics, 37(2), 462-472 (2014-12-04)
The primary aim of this study was to evaluate whether there was clinically significant pharmacokinetic (PK) interaction between finasteride and tamsulosin in healthy Chinese male subjects. This was an open-label, randomized, 3-period, crossover study. Subjects received single and multiple doses
Thomas Kunit et al.
American journal of physiology. Renal physiology, 307(7), F823-F832 (2014-07-25)
Smooth muscle contraction may be critical for lower urinary tract symptoms (LUTS) in patients with benign prostate hyperplasia and requires stable anchorage of the cytoskeleton to the cell membrane. These connections are regulated by focal adhesion kinase (FAK). Here, we
S Kimsakulvech et al.
Andrologia, 47(3), 354-359 (2014-04-02)
Male temporary contraception is occasionally required in some animals. Alpha1-adrenoceptor antagonist (tamsulosin) can cause ejaculation disorder. Two sets of Latin square were applied to six male goats to received either normal saline, dimethylsulphoxide or tamsulosin (179.8 nmol kg(-1) ) at 1-week interval.

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