T1331
Tat-Beclin 1
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About This Item
Linear Formula:
Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Gly-Thr-Asn-Val-Phe-Asn-Ala-Thr-Phe-Glu-Ile-Trp-His-Asp-Gly-Glu-Phe-Gly-Thr
CAS Number:
Molecular Weight:
3741.10
NACRES:
NA.32
UNSPSC Code:
12352200
Form:
lyophilized powder
Assay:
≥95% (HPLC)
General description
The TAT-BECLIN-1 (autophagy activator) peptide is derived from a region of the autophagy protein, beclin 1, attached to the HIV-1 Tat protein transduction domain. The peptide includes 11 amino acids at the N terminus derived from the Tat protein transduction domain, 18 amino acids (267–284 aa) from beclin 1 at the C terminus and a GG linker.
Biochem/physiol Actions
The TAT-BECLIN-1 (autophagy activator) peptide reduces the accumulation of polyglutamine aggregates and pathogen replication in vitro. This peptide is also found to reduce the mortality of mice infected by different viruses. The TAT-BECLIN-1 peptide is predicted to stimulate cell death via autophagy.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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