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T1455

TNP-470

≥98% (HPLC)

Synonym(s):

(Chloracetyl) carbamic acid (3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester, AGM-1470, NSC 642492, O-Chloracetyl-carbamoyl fumagillol

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About This Item

Empirical Formula (Hill Notation):
C19H28ClNO6
CAS Number:
129298-91-5
Molecular Weight:
401.88
NACRES:
NA.77
PubChem Substance ID:
329826676
UNSPSC Code:
12352200
MDL number:
MFCD00870281
Assay:
≥98% (HPLC)
Form:
solid
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >15 mg/mL

originator

Takeda

storage temp.

−20°C

SMILES string

CO[C@@H]1[C@@H](CC[C@]2(CO2)C1[C@@]3(C)O[C@@H]3C\C=C(\C)C)OC(=O)NC(=O)CCl

InChI

1S/C19H28ClNO6/c1-11(2)5-6-13-18(3,27-13)16-15(24-4)12(7-8-19(16)10-25-19)26-17(23)21-14(22)9-20/h5,12-13,15-16H,6-10H2,1-4H3,(H,21,22,23)/t12-,13-,15-,16-,18+,19+/m1/s1

InChI key

MSHZHSPISPJWHW-PVDLLORBSA-N

General description

TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.

Biochem/physiol Actions

Studies have reported that TNP-470 can decrease intimal neovascularization in Apo-E deficient mice. TNP-470 can also prevent tumor growth in human breast and prostate cancer cell lines.
TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.
TNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor.

Features and Benefits

This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

TNP-470 is soluble in DMSO at a concentration that is greater than 15 mg/ml.

Other Notes

TNP-470 is hygroscopic.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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