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T1512

Tetramisole hydrochloride

Name: Tetramisole hydrochloride
Brand: SIGMA

powder, ≥99% (TLC)

Synonym(s):

(±)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₂N₂S · HCl

CAS Number:

5086-74-8

Molecular Weight:

240.75

NACRES:

NA.77

PubChem Substance ID:

24278725

UNSPSC Code:

12352202

EC Number:

225-799-5

MDL number:

MFCD00005536

Beilstein/REAXYS Number:

4358989

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Product Name

Tetramisole hydrochloride, phosphatase inhibitor

biological source

synthetic (organic)

Quality Level

200

description

alkaline phosphatase inhibitor

assay

≥99% (TLC)

form

powder

mp

266-267 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

Cl[H].C1CN2CC(N=C2S1)c3ccccc3

InChI

1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H

InChI key

LAZPBGZRMVRFKY-UHFFFAOYSA-N

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Application

Structure-activity relationship for tetramisole derivatives as alkaline phosphatase inhibitors.

Suitable for inhibition of various mammalian alkaline phosphatases (i.e., liver, kidney, placenta, bone and tumor). Intestinal alkaline phosphatases are only slightly inhibited.

Other Notes

Racemic form of levamisole.

pictograms

GHS07

signalword

Warning

hcodes

H302,H315,H319,H335

pcodes

P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000374960

0000516550

0000444068

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Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.

Omer Yuval et al.

PLoS computational biology, 17(7), e1009185-e1009185 (2021-07-20)

Complex dendritic trees are a distinctive feature of neurons. Alterations to dendritic morphology are associated with developmental, behavioral and neurodegenerative changes. The highly-arborized PVD neuron of C. elegans serves as a model to study dendritic patterning; however, quantitative, objective and

Cell lineage-dependent chiral actomyosin flows drive cellular rearrangements in early Caenorhabditis elegans development.

Lokesh G Pimpale et al.

eLife, 9 (2020-07-10)

Proper positioning of cells is essential for many aspects of development. Daughter cell positions can be specified via orienting the cell division axis during cytokinesis. Rotatory actomyosin flows during division have been implied in specifying and reorienting the cell division

Kinetics and inhibition of alkaline phosphatases from canine tissues.

H Van Belle

Biochimica et biophysica acta, 289(1), 158-168 (1972-11-10)

A hydraulic instability drives the cell death decision in the nematode germline.

Nicolas T Chartier et al.

Nature physics, 17(8), 920-925 (2021-11-16)

Oocytes are large cells that develop into an embryo upon fertilization1. As interconnected germ cells mature into oocytes, some of them grow-typically at the expense of others that undergo cell death2-4. We present evidence that in the nematode Caenorhabditis elegans

Characterization of TAG-63 and its role on axonal transport in C. elegans.

Prerana Bhan et al.

Traffic (Copenhagen, Denmark), 21(2), 231-249 (2019-10-18)

Model organisms are increasingly used to study and understand how neurofilament (NF)-based neurological diseases develop. However, whether a NF homolog exists in C. elegans remains unclear. We characterize TAG-63 as a NF-like protein with sequence homologies to human NEFH carrying

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Global Trade Item Number

SKU	GTIN
T1512-5G	04061837337697
T1512-2G	04061833632260
T1512-10G	04061833632253

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