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T1573

Thrombin Receptor Activator Peptide 6

>95% (HPLC)

Synonym(s):

TRAP-6

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About This Item

Empirical Formula (Hill Notation):
C34H56N10O9
CAS Number:
141136-83-6
Molecular Weight:
748.87
NACRES:
NA.77
PubChem Substance ID:
329826680
UNSPSC Code:
12352200
MDL number:
MFCD00238172
Form:
lyophilized
Assay:
>95% (HPLC)

Key Documents

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Product Name

Thrombin Receptor Activator Peptide 6, >95% (HPLC)

solubility

water: soluble
0.1% TFA: soluble

InChI key

HAGOWCONESKMDW-FRSCJGFNSA-N

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O

InChI

1S/C34H56N10O9/c1-18(2)13-23(30(49)40-22(11-8-12-39-34(37)38)29(48)44-26(33(52)53)16-27(36)46)42-31(50)24(14-19(3)4)43-32(51)25(41-28(47)21(35)17-45)15-20-9-6-5-7-10-20/h5-7,9-10,18-19,21-26,45H,8,11-17,35H2,1-4H3,(H2,36,46)(H,40,49)(H,41,47)(H,42,50)(H,43,51)(H,44,48)(H,52,53)(H4,37,38,39)/t21-,22-,23-,24-,25-,26-/m0/s1

assay

>95% (HPLC)

form

lyophilized

technique(s)

cell culture | mammalian: suitable

UniProt accession no.

P25116

storage temp.

−20°C

Quality Level

200

Gene Information

human ... F2R(2149)

Biochem/physiol Actions

Hexapeptide fragment of the thrombin receptor (residues 42-47).
Hexapeptide fragment of the thrombin receptor (residues 42-47). Shown to activate the thrombin receptor and cause platelet aggregation (EC50 = 0.8 μM).

General description

Thrombin Receptor Activator Peptide 6 (TRAP-6) protects astrocytes from cell death, which is associated with hypoglycemia. TRAP-6 induced aggregation and impaired adhesion to collagen under flow conditions.

Other Notes

Lyophilized from 0.1% TFA in H2O

Application

Thrombin Receptor Activator Peptide 6 has been used to activate platelets in vitro. It has also been used to downregulate hippo signaling and increase nuclear yes-associated protein (YAP).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000430567
0000430567
0000278383
0000278383
0000177732

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Hematology: Basic Principles and Practice E-Book: Basic Principles and Practice (2017)
Kristoffer Navred et al.
PloS one, 14(1), e0211130-e0211130 (2019-01-24)
Flow cytometric platelet activation has emerged as an alternative diagnostic test for inherited platelet disorders. It is, however, labor intensive and few studies have directly compared the performance of flow cytometric platelet activation (PACT) to light transmission aggregometry (LTA). The
Xavier Charest-Morin et al.
Frontiers in immunology, 9, 2183-2183 (2018-10-20)
Multiple pathways have been proposed to generate bradykinin (BK)-related peptides from blood. We applied various forms of activation to fresh blood obtained from 10 healthy subjects or 10 patients with hereditary angioedema (HAE-1 or -2 only) to investigate kinin formation.
Alberto Zanetto et al.
Cancers, 13(5) (2021-04-04)
Hyper-functional platelets are being proposed as a potential therapeutic target in multiple cancers. Whether this can be considered in patients with cirrhosis and hepatocellular carcinoma (HCC) is unknown as their platelet function has not yet been investigated. We evaluated platelet
Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis
Johnson KE, et al.
Blood advances, 3(2), 198-211 (2019)
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