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T1892

Thioflavine S

Practical grade, powder

Synonym(s):

Direct Yellow 7

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About This Item

CAS Number:
1326-12-1
NACRES:
NA.47
UNSPSC Code:
12171500
EC Number:
215-418-0
MDL number:
MFCD00071453
Colour Index Number:
49010
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Product Name

Thioflavine S, practical grade

grade

practical grade

Quality Level

200

form

powder

technique(s)

microbe id | staining: suitable

color

light beige to dark beige, to Dark Brown

solubility

ethanol: water (1:1): 1 mg/mL

λmax

360-380

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]

InChI

1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1

InChI key

JADVWWSKYZXRGX-UHFFFAOYSA-M

Related Categories

General description

Thioflavine S aids in staining and visualizing β-amyloid plaques in Alzheimer′s disease. Thioflavin S binds to fibrillar β-amyloid plaques, and does not diffuse in the plaques. Thioflavin-S staining aids in visualizing smaller plaques throughout the neocortex, hippocampus and thalamic region.

Application

Thioflavine S has been used to stain and visualize β-amyloid structures in the tissue sections.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SHBS5830
SHBR0688
SHBP5084
SHBM5906
MKCH4108

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Mu Zhang et al.
Theranostics, 8(15), 4262-4278 (2018-08-22)
Rationale: It has been reported that peroxisome proliferator activated receptor γ (PPARγ) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear. This study aims to unravel the mechanism that amyloid
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
Meadowcroft MD, et al.
Journal of Magnetic Resonance Imaging : JMRI, 29(5), 997-1007 (2009)
Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Disha Shah et al.
PloS one, 8(12), e84241-e84241 (2013-12-21)
Functional connectivity (FC) studies have gained immense popularity in the evaluation of several neurological disorders, such as Alzheimer's disease (AD). AD is a complex disorder, characterised by several pathological features. The problem with FC studies in patients is that it
Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
Racke MM, et al.
The Journal of Neuroscience, 25(3), 629-636 (2005)
View All Related Papers

Global Trade Item Number

SKUGTIN
T1892-25G04061837338335

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