T1892
Thioflavine S
Practical grade, powder
Synonym(s):
Direct Yellow 7
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About This Item
CAS Number:
NACRES:
NA.47
UNSPSC Code:
12171500
EC Number:
215-418-0
MDL number:
Colour Index Number:
49010
Product Name
Thioflavine S, practical grade
grade
practical grade
Quality Level
form
powder
technique(s)
microbe id | staining: suitable
color
light beige to dark beige, to Dark Brown
solubility
ethanol: water (1:1): 1 mg/mL
λmax
360-380
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
SMILES string
S1c2c(ccc(c2)C)N(C1=C3C=CC(=[N+](C)C)C=C3)C.[Cl-]
InChI
1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChI key
JADVWWSKYZXRGX-UHFFFAOYSA-M
General description
Thioflavine S aids in staining and visualizing β-amyloid plaques in Alzheimer′s disease. Thioflavin S binds to fibrillar β-amyloid plaques, and does not diffuse in the plaques. Thioflavin-S staining aids in visualizing smaller plaques throughout the neocortex, hippocampus and thalamic region.
Application
Thioflavine S has been used to stain and visualize β-amyloid structures in the tissue sections.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Mu Zhang et al.
Theranostics, 8(15), 4262-4278 (2018-08-22)
Rationale: It has been reported that peroxisome proliferator activated receptor γ (PPARγ) level decreases significantly in the brains of Alzheimer's disease (AD) patients and mice models, while the mechanism is unclear. This study aims to unravel the mechanism that amyloid
MRI and histological analysis of beta-amyloid plaques in both human Alzheimer's disease and APP/PS1 transgenic mice
Meadowcroft MD, et al.
Journal of Magnetic Resonance Imaging : JMRI, 29(5), 997-1007 (2009)
Attenuation of beta-amyloid deposition and neurotoxicity by chemogenetic modulation of neural activity
Yuan P and Grutzendler J
The Journal of Neuroscience, 36(2), 632-641 (2016)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T1892-25G | 04061837338335 |