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Merck
CN

T3001

(+)-α-Tocopherol acetate

oil or semi-solid, ~1360 IU/g

Synonym(s):

Vitamin E acetate

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About This Item

Empirical Formula (Hill Notation):
C31H52O3
CAS Number:
58-95-7
Molecular Weight:
472.74
PubChem Substance ID:
24900095
eCl@ss:
34058007
UNSPSC Code:
12352205
NACRES:
NA.79
EC Number:
200-405-4
MDL number:
MFCD00072052

Key Documents

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Product Name

(+)-α-Tocopherol acetate, oil or semi-solid, ~1360 IU/g

InChI key

ZAKOWWREFLAJOT-CEFNRUSXSA-N

InChI

1S/C31H52O3/c1-21(2)13-10-14-22(3)15-11-16-23(4)17-12-19-31(9)20-18-28-26(7)29(33-27(8)32)24(5)25(6)30(28)34-31/h21-23H,10-20H2,1-9H3/t22-,23-,31-/m1/s1

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(C)=O)c(C)c(C)c2O1

biological source

plant

description

Synthesized from natural α-tocopherol

form

oil or semi-solid

specific activity

~1360 IU/g

color

yellow

mp

~25 °C (lit.)

storage temp.

room temp

Quality Level

200

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Application

(+)-α-Tocopherol acetate has been used:
  • as a component of growth medium for retinal cell lines
  • as an external standard in high performance liquid chromatography (HPLC) to study its composition in leafy vegetables
  • in the preparation of trans-resveratrol-encapsulated lipid nanocarriers (R-nano)

Biochem/physiol Actions

α-Tocopherol is also known as a radical-chain breaker due to its anti-oxidant property.
Tocopherols (TCP) (vitamin E) are a series (α, β,γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Tocopherol acetate has properties similar but not identical to α-tocopherol.

Disclaimer

Does not air oxidize.

General description

α-Tocopherol acetate is a fat soluble vitamin and a form of vitamin E. It can be obtained through dietary sources. RRRα-Tocopherol is a natural form of α-tocopherol.

hcodes

H413

Hazard Classifications

Aquatic Chronic 4

Storage Class

10 - Combustible liquids

wgk

WGK 1

ppe

Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCW1831
MKCR4700
MKCL9423
MKCG3201
MKBV1182V

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Partial nutrient characterization of arugula (rocket-Eruca sativa L.) and the effect of heat treatment on its lipoxidase activity
Tassi EMM, et al.
Brazilian Journal of Food Technology, 21 (2018)
Effects of natural (RRR α-tocopherol acetate) or synthetic (all-rac α-tocopherol acetate) vitamin E supplementation on reproductive efficiency in beef cows.
Horn M, Gunn P, Van Emon M, et al.
Journal of Animal Science, 88, 3121-3127 (2011)
Safety assessment of the substance alpha-tocopherol acetate for use in food contact materials
Bolognesi C, et al.
EFSA Journal, 14(3), 4412-4412 (2016)
Resveratrol liposomes and lipid nanocarriers: comparison of characteristics and inducing browning of white adipocytes
Zu Y, et al.
Colloids and Surfaces. B, Biointerfaces, 164, 414-423 (2018)
Jun Li et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 49(10), 2706-2709 (2011-07-06)
Phenobarbital (PB) is an efficacious and well-studied hepatic tumor promoting agent. Nuclear factor-κB (NF-κB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis. We previously found that PB activates NF-κB and that dietary
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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Vitamin E, Tocopherol, in Cell Culture

Importance and uses of vitamin E (tocopherol) in serum-free eukaryotic, including hybridoma and chinese hamster ovary (CHO), cell cultures.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

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