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T3126

D-α-Tocopherol succinate

Name: <SC>D</SC>-α-Tocopherol succinate
Brand: SIGMA

semisynthetic, 1210 IU/g

Synonym(s):

Vitamin E succinate

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About This Item

Empirical Formula (Hill Notation):

C₃₃H₅₄O₅

CAS Number:

4345-03-3

Molecular Weight:

530.78

NACRES:

NA.28

PubChem Substance ID:

24900107

eCl@ss:

34058016

UNSPSC Code:

12352205

EC Number:

224-403-8

MDL number:

MFCD00072055

Beilstein/REAXYS Number:

4038233

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biological source

semisynthetic

Quality Level

200

form

powder

specific activity

1210 IU/g

color

white to yellow

storage temp.

room temp

SMILES string

CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(OC(=O)CCC(O)=O)c(C)c(C)c2O1

InChI

1S/C33H54O5/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-20-33(8)21-19-28-27(7)31(25(5)26(6)32(28)38-33)37-30(36)18-17-29(34)35/h22-24H,9-21H2,1-8H3,(H,34,35)/t23-,24-,33-/m1/s1

InChI key

IELOKBJPULMYRW-NJQVLOCASA-N

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Related Categories

Biochemicals

Cell Culture Supplements & Reagents

Vitamins

General description

α-Tocopherol succinate is a fat soluble vitamin. α-Tocopherol is a form of vitamin E, which can be obtained through dietary sources. RRR-α-tocopherol is a natural form of α-Tocopherol.

Application

D-α-Tocopherol succinate has been used:

to as a dietary supplement to study its immunomodulatory effects in chicks
as a dietary supplement in pregnant women to evaluate its effects on arsenic exposure
as an antioxidant to investigate concurrent pathways of cell death due to acute exercise

Biochem/physiol Actions

α-Tocopherol is also called as a radical-chain breaker due to its anti-oxidant property.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. α-Tocopherol succinate is used along the α-Tocopherol acetate, α-Tocopherol nicotinate and other esterified forms as a vitamin E supplement with similar but differential activities.

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Myocardial apoptosis and mesenchymal stem cells with acute exercise.

Maria F Arisi et al.

Physiological reports, 5(11) (2017-06-04)

Aerobic exercise confers many health benefits. However, numerous reports have shown that acute aerobic exercise can injure the heart. We tested the general hypothesis that acute moderate-intensity exercise in rodents induces cardiomyocyte damage and stimulates mesenchymal stem cells (MSCs) to

Effects of immunomodulatory nutrients on growth performance and immune-related gene expression in layer chicks challenged with lipopolysaccharide

Wils-Plotz EL and Klasing KC

Poultry Science, 96(3), 548-555 (2017)

Curcumin and vitamin E protect against adverse effects of benzo[a]pyrene in lung epithelial cells.

Wenbin Zhu et al.

PloS one, 9(3), e92992-e92992 (2014-03-26)

Benzo[a]pyrene (BaP), a well-known environmental carcinogen, promotes oxidative stress and DNA damage. Curcumin and vitamin E (VE) have potent antioxidative activity that protects cells from oxidative stress and cellular damage. The objectives of the present study were to investigate the

Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E

Azzi A

Redox Biology, 101259-101259 (2019)

Radioprotective efficacy of tocopherol succinate is mediated through granulocyte-colony stimulating factor.

Pankaj K Singh et al.

Cytokine, 56(2), 411-421 (2011-09-02)

The purpose of this study was to elucidate the role of granulocyte colony-stimulating factor (G-CSF) induced by α-tocopherol succinate (TS) in protecting mice from total-body irradiation. CD2F1 mice were injected with a radioprotective dose of TS and the levels of

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Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

膳食抗氧化剂

抗氧化剂可保护生物系统免受含氧自由基和氧化还原过渡金属离子（如铁、铜和镉）引起的氧化损伤。

Global Trade Item Number

SKU	GTIN
T3126-25G	04061833624739
T3126-100G	04061833624722
T3126-5G	04061837343728

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