T3763
α-Thymidine
≥98% (HPLC), powder
Synonym(s):
1-(2-Deoxy-α-D-ribofuranosyl)-5-methyluracil
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About This Item
Empirical Formula (Hill Notation):
C10H14N2O5
CAS Number:
Molecular Weight:
242.23
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
Product Name
α-Thymidine,
Assay
≥98% (HPLC)
Quality Level
form
powder
optical activity
[α]25/D 5.0 to 8.0°, c = 2.0% in water
solubility
water: 50 mg/mL, clear, colorless
SMILES string
CC1=CN(C2CC(O)C(CO)O2)C(=O)NC1=O
InChI
1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)
InChI key
IQFYYKKMVGJFEH-UHFFFAOYSA-N
Application
α-Thymidine (α-Thymidine) is the unnatural epimer of thymidine.
Other Notes
Unnatural epimer
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Carolina H Andrade et al.
Journal of chemical information and modeling, 49(4), 1070-1078 (2009-03-20)
Thymidine monophosphate kinase (TMPK) has emerged as an attractive target for developing inhibitors of Mycobacterium tuberculosis growth. In this study the receptor-independent (RI) 4D-QSAR formalism has been used to develop QSAR models and corresponding 3D-pharmacophores for a set of 5'-thiourea-substituted
Y Sato et al.
Nucleic acids symposium series, 44(44), 31-32 (2003-08-09)
In this paper, we report the synthesis of hydroxymethylphosphonate alpha-DNAs and related compounds by use of the H-phosphonate method. These modified alpha-DNAs were designed to improve the inherent poor solubility of well-known methylphosphonate alpha-DNAs by introduction of a more hydrophilic
Sara Van Poecke et al.
Bioorganic & medicinal chemistry, 19(24), 7603-7611 (2011-11-09)
We report on Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) inhibitory activities of a series of new 3'- and 5'-modified thymidine analogues including α- and β-derivatives. In addition, several analogues were synthesized in which the 4-oxygen was replaced by a more
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