T4510
Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt
chromogenic, ≥98% (HPLC), powder
Synonym(s):
p-Nitrophenyl-5V-thymidine-monophosphate, p-Nph-5V-TMP
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About This Item
Empirical Formula (Hill Notation):
C16H18N3O10PNa
CAS Number:
Molecular Weight:
466.29
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
Product Name
Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
water: 50 mg/mL
storage temp.
−20°C
SMILES string
CC(C(N1)=O)=CN([C@H]2C[C@H](O)[C@@H](COP(O)(OC(C=C3)=CC=C3[N+]([O-])=O)=O)O2)C1=O.[Na]
InChI
1S/C16H18N3O10P.Na.H/c1-9-7-18(16(22)17-15(9)21)14-6-12(20)13(28-14)8-27-30(25,26)29-11-4-2-10(3-5-11)19(23)24;;/h2-5,7,12-14,20H,6,8H2,1H3,(H,25,26)(H,17,21,22);;
InChI key
PHNRUCBIIRECII-UHFFFAOYSA-N
General description
A sensitive chromogenic substrate for venom phosphodiesterase. It is not hydrolyzed by bovine spleen phosphodiesterase.
Application
Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt has been used as a substrate for assessing phosphodiesterase activity. It is also been used as a nucleotide analog in the autotaxin inhibition assay.
Biochem/physiol Actions
Thymidine 5′-monophosphate p-nitrophenyl ester sodium salt is an artificial substrate marker for 5′-nucleotide phosphodiesterase enzyme activity. It is also used as a substrate for autotaxin (ATX, NPP2), which is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (NPP) enzyme family.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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