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T4567

Transforming Growth Factor-β Soluble Receptor III human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Synonym(s):

TGF-β sRIII

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About This Item

UNSPSC Code:
51111800
MDL number:
MFCD01324821
Form:
lyophilized powder
Assay:
>97% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in NSO cells
Mol wt:
100 kDa by SDS-PAGE (glycosylation), predicted mol wt 84 kDa
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biological source

human

recombinant

expressed in NSO cells

assay

>97% (SDS-PAGE)

form

lyophilized powder

mol wt

100 kDa by SDS-PAGE (glycosylation), predicted mol wt 84 kDa

packaging

pkg of 1 mg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

impurities

endotoxin, tested

UniProt accession no.

Q03167

storage temp.

−20°C

Gene Information

human ... TGFBR3(7049)

Application

Transforming Growth Factor-β soluble receptor III human can be used to study TGF-β- mediated signal tranduction.

Biochem/physiol Actions

Transforming Growth Factor-β soluble receptor III human also known as betaglycan facilitates as an inhibin co-receptor with ActRII and mediates functional antagonism of activin signalling.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 5 mg bovine serum albumin

Analysis Note

The receptor-mediated activity is measured by its ability to inhibit the TGF-β2 bioactivity in HT-2 cells.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
095K1102
072K0753
100K0037

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K A Lewis et al.
Nature, 404(6776), 411-414 (2000-04-04)
Activins and inhibins, structurally related members of the TGF-beta superfamily of growth and differentiation factors, are mutually antagonistic regulators of reproductive and other functions. Activins bind specific type II receptor serine kinases (ActRII or IIB) to promote the recruitment and
M L Tsang et al.
Cytokine, 7(5), 389-397 (1995-07-01)
Recombinant human transforming growth factor soluble receptor Type II (rhTGF-beta sRII) corresponding to the 159 amino acid extracellular domain of hTGF-beta RII has been expressed in insect cells using the baculovirus expression system or in a mouse myeloma cell line.

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Global Trade Item Number

SKUGTIN
T4567-.1MG04061837346446

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